{
  "abstract": "Background: Whether low magnesium status after sepsis is associated with subsequent diabetes remains uncertain. We examined the association between post-sepsis magnesium status and newly recorded diabetes among adult sepsis survivors.\n\nMethods: We conducted a retrospective multicenter cohort study using the TriNetX Global Collaborative Network. Adults with a qualifying magnesium measurement between 2010 and 2023 and a history of sepsis were classified as having low magnesium (< 1.80 mg/dL) or normal magnesium (1.80–2.20 mg/dL). Patients with diabetes or hemoglobin A1c (HbA1c) ≥ 6.5% before the index date were excluded, and a 90-day landmark was applied. After 1:1 propensity score matching, 15,201 patients remained in each group. The primary outcome was a diabetes composite outcome, defined as newly recorded type 2 diabetes mellitus (T2DM) or HbA1c ≥ 6.5%. Secondary outcomes included the individual composite components, all-cause mortality, other diabetes diagnoses, and HbA1c ≥ 9.0%. Outcomes were assessed from day 90 through day 730 after the index date.\n\nResults: The diabetes composite occurred in 3.31% of the low-magnesium group and 2.38% of controls (absolute risk difference, 0.93 percentage points; hazard ratio [HR], 1.43; 95% confidence interval [CI], 1.25–1.63). Associations were consistent for newly recorded T2DM (HR, 1.38; 95% CI, 1.19–1.59) and HbA1c ≥ 6.5% (HR, 1.51; 95% CI, 1.21–1.89). Low magnesium was also associated with higher all-cause mortality (HR, 1.22; 95% CI, 1.12–1.33) and other diabetes diagnoses (HR, 1.78; 95% CI, 1.12–2.84), whereas HbA1c ≥ 9.0% was not significantly increased. The association with the primary outcome remained generally consistent across several sensitivity analyses and when severe magnesium deficiency (< 1.5 mg/dL) defined the exposure (HR, 1.53; 95% CI, 1.26–1.85).\n\nConclusions: Among adult sepsis survivors without recognized diabetes, low magnesium status was associated with a modestly higher subsequent risk of newly recorded diabetes and mortality. These findings support magnesium as a potential post-sepsis risk marker but do not establish causality.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Anesthesiology, Chi Mei Medical Center",
    "Department of Anesthesiology, E-Da Hospital, I-Shou University",
    "School of Medicine, College of Medicine, National Sun Yat-sen University",
    "Department of Anesthesiology, Chi Mei Hospital"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yu-Li Pang"
    },
    {
      "affs": [
        1
      ],
      "name": "Li-Chen Chang"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Ping-Heng Tan"
    },
    {
      "affs": [
        3
      ],
      "name": "Su-Zhen Wu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8nct6yqa86bek.bib",
  "cited_by": 0,
  "doi": "10.3389/fendo.2026.2017989",
  "fulltext_url": null,
  "id": "8nct6yqa86bek",
  "issns": [
    "1664-2392"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fendo.2026.2017989/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-04",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/8nct6yqa86bek.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:21:48Z",
      "native_id": "10.3389/fendo.2026.2017989",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fendo.2026.2017989/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:1664-2392",
      "subfield": "endocrinology-metabolism"
    }
  ],
  "title": "Post-sepsis low magnesium status and newly recorded diabetes: a propensity score–matched cohort study",
  "title_text": "Post-sepsis low magnesium status and newly recorded diabetes: a propensity score–matched cohort study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T00:21:27Z",
  "url": "https://research.draconitic.com/paper/8nct6yqa86bek",
  "venue": "Frontiers in Endocrinology",
  "versions": []
}