{
  "abstract": "Sulfur hexafluoride (SF 6 ), a chemically inert and stable gas essential to the electric power industry, poses severe environmental risks due to its persistence and high global warming potential. While traditional degradation methods are inefficient, photocatalytic single electron reduction (SER) enables SF 6 activation into SF 5 radicals, creating opportunities for both degradation and reutilization. The SF 5 group, renowned for its strong electron‐withdrawing, lipophilic, and bioisosteric features, has great potential in drug discovery, while efficient methods for synthesizing alkyl‐ or BCP‐SF 5 motifs remain scarce. As a safe, inexpensive, and atom‐economical alternative to conventional SF 5 reagents, SF 6 serves as an ideal yet underexplored SF 5 source. Herein, we present a photocatalytic strategy for the direct synthesis of diverse SF 5 ‐containing scaffolds, including ketones, acetals, and bicyclo[1.1.1]pentane derivatives. Derivatization studies demonstrate its synthetic versatility, particularly in accessing α‐SF 5 ‐substituted acetaldehydes. Mechanistic and density functional theory (DFT) studies confirm the single electron reduction of SF 6 , highlighting a mild, efficient, and broadly applicable route for constructing SF 5 ‐functionalized architectures in fluorinated drug development.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry University of Science and Technology of China Hefei China",
    "Department of Pharmacy Division of Life Sciences and Medicine The First Affiliated Hospital of USTC University of Science and Technology of China Hefei China",
    "State Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences Shanghai China",
    "State Grid Anhui electric Power Research Institute Hefei Anhui China",
    "School of Chemistry and Materials Science Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences Hangzhou China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Chen‐Hui Jiang"
    },
    {
      "affs": [
        2
      ],
      "name": "HJ Xu",
      "orcid": "0000-0003-3831-4577"
    },
    {
      "affs": [
        0
      ],
      "name": "Yang Yi-gang"
    },
    {
      "affs": [
        1
      ],
      "name": "Xuan Nie",
      "orcid": "0000-0002-7757-9538"
    },
    {
      "affs": [
        2
      ],
      "name": "Meng-Meng Zheng",
      "orcid": "0009-0008-8976-9778"
    },
    {
      "affs": [
        3
      ],
      "name": "Yue Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Ya-Wen Zuo"
    },
    {
      "affs": [
        0
      ],
      "name": "Wei‐Ran Ren"
    },
    {
      "affs": [
        3
      ],
      "name": "Shan Zhu"
    },
    {
      "affs": [
        0
      ],
      "name": "Ruo‐Xing Jin",
      "orcid": "0000-0002-6381-148X"
    },
    {
      "affs": [
        4,
        2
      ],
      "name": "Xiao‐Song Xue",
      "orcid": "0000-0003-4541-8702"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Xi-Sheng Wang",
      "orcid": "0000-0003-2398-5669"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8nh4b165q5e4g.bib",
  "cited_by": 6,
  "doi": "10.1002/advs.75663",
  "fulltext_url": null,
  "id": "8nh4b165q5e4g",
  "issns": [
    "2198-3844"
  ],
  "landing_url": "https://doi.org/10.1002/advs.75663",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Radical Photochemical Reactions"
    ]
  ],
  "openalex": "W7161294788",
  "pdf_url": null,
  "pmcid": "PMC13336085",
  "pmid": "42138823",
  "published": "2026-05-15",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/8nh4b165q5e4g.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:26:44Z",
      "native_id": "W7161294788",
      "source": "openalex",
      "url": "https://doi.org/10.1002/advs.75663"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Radical Photochemical Reactions",
      "subfield": "organic"
    }
  ],
  "title": "Photocatalytic Synthesis of Pentafluorosulfanyl Ketones, Acetals, and BCP Motifs Utilizing SF 6",
  "title_text": "Photocatalytic Synthesis of Pentafluorosulfanyl Ketones, Acetals, and BCP Motifs Utilizing SF 6",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T13:21:03Z",
  "url": "https://research.draconitic.com/paper/8nh4b165q5e4g",
  "venue": "Advanced Science",
  "versions": []
}