{
  "abstract": "Chronic enteropathy associated with SLCO2A1 (CEAS) is a rare condition that can mimic fibrostenosing Crohn's disease. We describe a young man with presumed Crohn's disease marked by recurrent bowel obstruction, multiple surgical resections, and poor response to standard therapies, with histopathology showing atypical findings. He developed systemic manifestations of CEAS, including pachydermoperiostosis (digital clubbing, periosteal new bone formation, and skin thickening) and hypertrophic osteoarthropathy. Subsequent genetic testing identified a pathogenic SLCO2A1 mutation. Treatment with COX-2 and PDE-4 inhibitors, combined with conventional therapy, reduced disease activity, underscoring the importance of recognizing atypical features and early genetic testing.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Internal Medicine, Emory University School of Medicine, Atlanta, GA",
    "Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA",
    "Department of Medicine, Vanderbilt University Medical Center, Nashville, TN",
    "Department of Medicine & Rheumatology, Emory University, Atlanta, GA",
    "Department of Digestive Diseases, Emory University, Atlanta, GA"
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Hayalneh Gessessew"
    },
    {
      "affs": [
        1
      ],
      "name": "David Qin"
    },
    {
      "affs": [
        2
      ],
      "name": "Navila Sharif"
    },
    {
      "affs": [
        3
      ],
      "name": "Prateek Gandiga"
    },
    {
      "affs": [
        4
      ],
      "name": "Heba Iskandar"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8pffjy167z54n.bib",
  "cited_by": 0,
  "doi": "10.14309/crj.0000000000002388",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13722499/?tool=EBI",
  "id": "8pffjy167z54n",
  "issns": [
    "2326-3253"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13722499",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Case Report"
    ],
    [
      "heading",
      "Inflammatory Bowel Disease"
    ],
    [
      "openalex",
      "1311|Inflammatory Bowel Disease"
    ]
  ],
  "openalex": "W7224881748",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13722499/pdf/?tool=EBI",
  "pmcid": "PMC13722499",
  "pmid": "42964936",
  "published": "2026-10-30",
  "publisher": "American College of Gastroenterology",
  "ris": "https://research.draconitic.com/paper/8pffjy167z54n.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:37Z",
      "native_id": "PMC:PMC13722499",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13722499"
    },
    {
      "first_seen": "2026-11-03T12:22:59Z",
      "native_id": "PMC13722499",
      "source": "pmc",
      "url": "https://doi.org/10.14309/crj.0000000000002388"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1311|Inflammatory Bowel Disease",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "Chronic Enteropathy Associated With SLCO2A1 Gene Mutation; Initially Misdiagnosed as Fibrostenosing Crohn's Disease",
  "title_text": "Chronic Enteropathy Associated With SLCO2A1 Gene Mutation; Initially Misdiagnosed as Fibrostenosing Crohn's Disease",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:22:59Z",
  "url": "https://research.draconitic.com/paper/8pffjy167z54n",
  "venue": "ACG case reports journal",
  "versions": []
}