{
  "abstract": "Pulmonary hypertension (PH) encompasses a heterogeneous group of disorders characterized by persistently elevated pulmonary artery pressure and driven by diverse etiologies and intersecting pathological mechanisms. In recent years, substantial advances have clarified key contributors to PH pathogenesis, including pulmonary vascular remodeling, immune–inflammatory dysregulation, and genetic predispositions. Concurrently, diagnostic and therapeutic approaches tailored to different PH subtypes have evolved, incorporating targeted pharmacological treatments, interventional procedures, and lung transplantation. This review summarizes recent advances in elucidating the mechanisms underlying PH and outlines clinical management strategies across the major etiologic categories. Particular emphasis is placed on developments in PH-specific therapies and on emerging therapeutic targets to provide a coherent mechanistic framework and practical guidance for clinicians involved in the diagnosis and treatment of this challenging disease.",
  "abstract_shown": true,
  "affiliations": [
    "Chinese Academy of Medical Sciences & Peking Union Medical College, 100730 Beijing, China",
    "Department of Radiology, China-Japan Friendship Hospital, 100029 Beijing, China",
    "Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital; National Center for Respiratory Medicine; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; National Clinical Research Center for Respiratory Diseases, 100029 Beijing, China",
    "State Key Laboratory of Respiratory Health and Multimorbidity, China-Japan Friendship Hospital, 100029 Beijing, China",
    "Peking University Health Science Center, 100191 Beijing, China"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Anqi Liu",
      "orcid": "0009-0002-0934-892X"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Linfeng Xi",
      "orcid": "0000-0001-5702-4159"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jie Du",
      "orcid": "0009-0000-8556-9068"
    },
    {
      "affs": [
        1
      ],
      "name": "Yanlin Guo",
      "orcid": "0009-0005-9758-9177"
    },
    {
      "affs": [
        4
      ],
      "name": "Hanchi Yu",
      "orcid": "0009-0000-5731-1895"
    },
    {
      "affs": [
        2
      ],
      "name": "Shuai Zhang",
      "orcid": "0000-0003-3247-5847"
    },
    {
      "affs": [
        2
      ],
      "name": "Wanmu Xie",
      "orcid": "0000-0002-6686-3517"
    },
    {
      "affs": [
        1,
        3
      ],
      "name": "Min Liu",
      "orcid": "0000-0003-1298-4441"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8pxcvhea5y3sp.bib",
  "cited_by": 0,
  "doi": "10.31083/rcm49075",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13732665/",
  "id": "8pxcvhea5y3sp",
  "issns": [
    "1530-6550",
    "2153-8174"
  ],
  "landing_url": "https://doi.org/10.31083/rcm49075",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "2740|Pulmonary Hypertension Research and Treatments"
    ]
  ],
  "openalex": "W7225261854",
  "pdf_url": "https://storage.imrpress.com/IMR/2110287741665124400/application/2153-8174-27-10-49075.pdf",
  "pmcid": "PMC13732665",
  "pmid": "42985582",
  "published": "2026-10-14",
  "publisher": "IMR Press",
  "ris": "https://research.draconitic.com/paper/8pxcvhea5y3sp.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:22:36Z",
      "native_id": "PMC13732665",
      "source": "pmc",
      "url": "https://doi.org/10.31083/rcm49075"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:2705|Acute Myocardial Infarction Research",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Advances in Mechanisms and Management Strategies of Pulmonary Hypertension: A Review",
  "title_text": "Advances in Mechanisms and Management Strategies of Pulmonary Hypertension: A Review",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:22:36Z",
  "url": "https://research.draconitic.com/paper/8pxcvhea5y3sp",
  "venue": "Reviews in Cardiovascular Medicine",
  "versions": []
}