{
  "abstract": "For the first time, new natural chlorin derivatives containing tetrahydropyridine and thioimide exocycles have been synthesized. The spectral characteristics of the synthesized compounds were studied: for the thioimide, a bathochromic displacement of the long-wave absorption maximum (by 33 nm) is shown, and the tetrahydropyridine derivative has a hypsochromic displacement of the Q2-band (by 52 nm) compared to the original purpurinimide. For the resulting sulfur-containing derivative, an increase in the quantum yield of singlet oxygen generation with almost complete fluorescence quenching was found, while for the tetrahydropyridine, singlet oxygen generation was reduced by half, while fluorescence increased five-fold. Both synthesized compounds had a high phototoxicity activity for both Gram-positive and Gram-negative strains of bacteria, which indicates their potential as photosensitizers for antimicrobial photodynamic therapy.",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Fine Chemical Technologies, MIREA-Russian Technological University, 86 Vernadsky Avenue, Moscow 119571, Russia",
    "Russian State University Named After A. N. Kosygin (Technologies. Design. Art), str Malaya Kaluzhskaya 1, Moscow 115035, Russia",
    "Department of Operative Surgery and Topographic Anatomy, I.M. Sechenov First Moscow State Medical University (Sechenov University), str Trubetskaya 8\\2, Moscow 119435, Russia",
    "Institute of Histology and Embryology, Faculty of Medicine, Comenius University in Bratislava, Sasinkova 4, 811 08 Bratislava, Slovakia"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Viktor A. Pogorilyy",
      "orcid": "0000-0003-3556-8600"
    },
    {
      "affs": [
        0
      ],
      "name": "Julia S. Kartava",
      "orcid": "0009-0001-4163-1728"
    },
    {
      "affs": [
        0
      ],
      "name": "Tanaka F. Tandare",
      "orcid": "0009-0003-6267-6962"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Victoria V. Shchelkova"
    },
    {
      "affs": [
        0
      ],
      "name": "Nikita V. Suvorov",
      "orcid": "0000-0002-2749-3656"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Yuriy L. Vasil’ev"
    },
    {
      "affs": [
        2
      ],
      "name": "Sergey S. Dydykin",
      "orcid": "0000-0002-1273-0356"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Ivan Varga",
      "orcid": "0000-0002-0918-741X"
    },
    {
      "affs": [
        0
      ],
      "name": "Michael A. Grin"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8q651z8g0smyn.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27219845",
  "fulltext_url": null,
  "id": "8q651z8g0smyn",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://www.mdpi.com/1422-0067/27/21/9845",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-03",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/8q651z8g0smyn.ris",
  "sources": [
    {
      "first_seen": "2026-11-05T00:20:58Z",
      "native_id": "10.3390/ijms27219845",
      "source": "crossref",
      "url": "https://www.mdpi.com/1422-0067/27/21/9845"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "issn:1422-0067",
      "subfield": "general"
    }
  ],
  "title": "Novel Chlorin Derivatives with a Modified Exocycle E: A Study of Spectral and Biological Properties",
  "title_text": "Novel Chlorin Derivatives with a Modified Exocycle E: A Study of Spectral and Biological Properties",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T00:21:14Z",
  "url": "https://research.draconitic.com/paper/8q651z8g0smyn",
  "venue": "International Journal of Molecular Sciences",
  "versions": []
}