{
  "abstract": "This study evaluated circulating mRNAs (B2M, TIMP-1, CLU, SERPINE1, GAL3, and S100A9) as potential biomarkers for colorectal cancer (CRC). Plasma levels were measured in CRC patients (stages I–IV, n = 178) and healthy individuals (HIs, n = 171). B2M, TIMP-1, CLU, and S100A9 mRNA levels were significantly elevated in CRC patients vs. HIs. B2M differed only in stage IV, while TIMP-1, CLU, and S100A9 showed significance across all stages except I. A composite index, I-BTC, was developed using B2M, TIMP-1, and CLU via logistic regression. I-BTC improved discrimination between HIs and CRC patients, even at stage I (p = 0.001), with stronger significance in later stages (p ≤ 0.0001). These results validate analytical robustness of the method and highlight its diagnostic potential including for early-stage CRC through spe- cific mRNAs combinations.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "name": "Thibault Mazard"
    },
    {
      "name": "Marie Grosgeorges"
    },
    {
      "name": "Laura Veyrie"
    },
    {
      "name": "Simon Thezenas"
    },
    {
      "name": "Brice Pastor"
    },
    {
      "name": "Ekaterina Pisareva"
    },
    {
      "name": "Gérald Lossaint"
    },
    {
      "name": "Evelyne Lopez-Crapez"
    },
    {
      "name": "Marc Ychou"
    },
    {
      "name": "Alain R Thierry"
    },
    {
      "name": "Corinne Prévostel"
    },
    {
      "name": "Philippe Blache"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8qv7fnqv08700.bib",
  "cited_by": 0,
  "doi": "10.1016/j.isci.2026.116398",
  "fulltext_url": null,
  "id": "8qv7fnqv08700",
  "issns": [
    "2589-0042"
  ],
  "landing_url": "https://hal.science/hal-05740964v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "1306|Cancer Genomics and Diagnostics"
    ]
  ],
  "openalex": "W7164995250",
  "pdf_url": "https://hal.science/hal-05740964/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-17",
  "publisher": "Cell Press, Elsevier [2018-....]",
  "ris": "https://research.draconitic.com/paper/8qv7fnqv08700.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:29Z",
      "native_id": "hal-05740964",
      "source": "hal",
      "url": "https://hal.science/hal-05740964v1"
    },
    {
      "first_seen": "2026-10-30T12:17:42Z",
      "native_id": "hal-05767315",
      "source": "hal",
      "url": "https://hal.science/hal-05767315v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1306|Cancer Genomics and Diagnostics",
      "subfield": "oncology"
    }
  ],
  "title": "An exploratory study of circulating cell-free mRNAs across colorectal cancer stages",
  "title_text": "An exploratory study of circulating cell-free mRNAs across colorectal cancer stages",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:42Z",
  "url": "https://research.draconitic.com/paper/8qv7fnqv08700",
  "venue": "iScience",
  "versions": []
}