{
  "abstract": "DNA Encoded Libraries (DELs) are used for finding small molecule binders to proteins and other targets of pharmaceutical interest. DELs tether small molecules made by combinatorial chemistry to DNA oligos whose sequences identify the molecules to which they are tethered. DEL selections, or screens, typically separate binders from non-binders and use sequencing to discern binder structures. Typically, selection methods more efficiently capture tighter binders than weaker ones. There are two key reasons why DEL selections may return very few, or no binders. One is the presence of only a few binders in the library (or none); less appreciated is the case where there are true binders, but the selection protocol lacks the sensitivity to capture them. We report in our “Theoretical Analysis of Bivalent Binding Avidity and Kinetics: Implications for DNA-Encoded Libraries” that through an avidity effect bivalent DELs increase the sensitivity of selections and capture more and weaker binders than their cognate monovalent counterparts. Here, we present our development of the means to efficiently build bivalent DELs.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "name": "Spurti U Akki"
    },
    {
      "name": "Yasmin Arjomandi"
    },
    {
      "name": "Tracy Chan"
    },
    {
      "name": "Kirill Novikov"
    },
    {
      "name": "Divya Kanichar"
    },
    {
      "name": "Patrick J McEnaney"
    },
    {
      "name": "Vincent Lee"
    },
    {
      "name": "Jacob H Pachter"
    },
    {
      "name": "Joshua L Turnbull"
    },
    {
      "name": "Nikhil Jain"
    },
    {
      "name": "Virja A Pandya"
    },
    {
      "name": "Nathaniel H Stanley"
    },
    {
      "name": "Dong Min Mun"
    },
    {
      "name": "Christoph Klein"
    },
    {
      "name": "Boris P Belotserkovskii"
    },
    {
      "name": "R. Edward Watts",
      "orcid": "0009-0006-8485-0003"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8ra133z4hfebk.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15008128/v1",
  "fulltext_url": null,
  "id": "8ra133z4hfebk",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15008128/v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Chemical Synthesis and Analysis"
    ]
  ],
  "openalex": "W7204942595",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15008128/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-31",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/8ra133z4hfebk.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:17Z",
      "native_id": "10.26434/chemrxiv.15008128",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15008128/v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Chemical Synthesis and Analysis",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Avidity by Design: Scalable Programmed Synthesis of Bivalent DNA-Encoded Libraries for Enhanced Selection Sensitivity",
  "title_text": "Avidity by Design: Scalable Programmed Synthesis of Bivalent DNA-Encoded Libraries for Enhanced Selection Sensitivity",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:17Z",
  "url": "https://research.draconitic.com/paper/8ra133z4hfebk",
  "venue": "ChemRxiv",
  "versions": []
}