{
  "abstract": "Tumor cells often develop reductive adaptations that decrease the effectiveness of reactive oxygen species (ROS)-dependent treatments, prompting a need for catalytic platforms that sustainably amplify redox stress. In this work, we constructed a bio-based protocatechuic acid (PCA)-anchored multimetallic Fe-based metal-organic framework (Fe-MOF) nanoreactor with magnetic resonance imaging (MRI) capability and redox-activated therapeutic potential. Combining the PCA-coordinated Fe 2+ /Fe 3+ framework with Cu + /Cu 2+ redox cycling and ultrasmall Au domains, this redox network formed a tightly interconnected Fe/Cu/Au catalytic system that supported Fenton-type conversion of H 2 O 2 into •OH, glutathione (GSH) depletion, and enhanced oxidative stress in tumor environments. The addition of the natural compound brazilin (BRA) promoted apoptosis and enhanced the sensitivity of tumor cells to ferroptosis. Surface coating with homotypic 4T1 cell membranes enabled tumor homing and facilitated BRA release within tumors. Mechanistically, the nanoreactor perturbed cellular redox regulation across multiple metabolic pathways, including reduced expression of cytochrome c oxidase subunit 4 isoform 1 (COX4I1), serine hydroxymethyltransferase 2 (SHMT2), and dihydroorotate dehydrogenase (DHODH), suppression of the glutathione peroxidase 4 (GPX4)-solute carrier family 7 member 11 (SLC7A11) antioxidant response, and acyl-CoA synthetase long-chain family member 4 (ACSL4)-mediated lipid remodeling. In general, PCA-ligated Fe-MOF sequentially modified with Au, Cu, BRA, and 4T1 cell membranes (FP@ACBM) enhanced ROS accumulation, promoted lipid peroxidation, and induced apoptosis, thus producing antitumor effects. At the same time, it enabled stable longitudinal relaxation time ( T 1 )-weighted MRI contrast enhancement. Overall, this bio-based phenolic ligand-assembled mixed-valence Fe-MOF platform provides a versatile strategy for constructing redox-cycling nanomaterials with promising biomedical applications.",
  "abstract_shown": true,
  "affiliations": [
    "The College of Forestry, Beijing Forestry University, Beijing 100083, China; State Key Laboratory of Efficient Production of Forest Resources, Beijing Forestry University, Beijing 100083, China",
    "College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin 150040, China",
    "Institute of Integration of Traditional and Western Medicine, Guangzhou Medical University, Guangzhou 511436, China; Artemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou 510006, China",
    "Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Mainz 55128, Germany"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Wanmei Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Litao Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Chengdong Nie"
    },
    {
      "affs": [
        2
      ],
      "name": "Zixin Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Qi Gu"
    },
    {
      "affs": [
        0
      ],
      "name": "Haiting Tian"
    },
    {
      "affs": [
        0
      ],
      "name": "Chenlu Wang"
    },
    {
      "affs": [
        3
      ],
      "name": "Thomas Efferth"
    },
    {
      "name": "Yujie Fu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8rqvgkapcmewq.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jobab.2026.100298",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S2369969826000708",
  "id": "8rqvgkapcmewq",
  "issns": [
    "2369-9698"
  ],
  "landing_url": "https://doi.org/10.1016/j.jobab.2026.100298",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QD415-436"
    ],
    [
      "openalex",
      "2204|Nanoplatforms for cancer theranostics"
    ]
  ],
  "openalex": "W7204915581",
  "pdf_url": "https://www.sciencedirect.com/science/article/pii/S2369969826000708/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-25",
  "publisher": "KeAi Communications Co., Ltd.",
  "ris": "https://research.draconitic.com/paper/8rqvgkapcmewq.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:44:51Z",
      "native_id": "135666525ff545ee845798df5014fd4b",
      "source": "doaj",
      "url": "https://doi.org/10.1016/j.jobab.2026.100298"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "lcc:QD415-436",
      "subfield": "general"
    }
  ],
  "title": "Bio-based protocatechuic acid-anchored multimetallic nanoreactors: Green construction, redox-cycling properties, and biomedical potential",
  "title_text": "Bio-based protocatechuic acid-anchored multimetallic nanoreactors: Green construction, redox-cycling properties, and biomedical potential",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T14:20:26Z",
  "url": "https://research.draconitic.com/paper/8rqvgkapcmewq",
  "venue": "Journal of Bioresources and Bioproducts",
  "versions": []
}