{
  "abstract": "Frequency-dependent sensory drive must pass through thalamocortical pathways before cortical expression, yet how high-frequency input is transformed into sustained cortical activity remains unclear. We combined 11.7-T fMRI, pathway-specific optogenetic stimulation, tuned-burst thalamic drive, and dynamic causal modeling (DCM) in dexmedetomidine-sedated rats to examine the ventral posterolateral thalamus (VPL)-to-primary somatosensory forelimb cortex (S1FL) pathway. Peripheral forepaw stimulation revealed intermediate-frequency cortical tuning, whereas thalamic nuclei remained responsive at high frequencies. Direct S1FL activation evoked sustained high-frequency blood-oxygen-level-dependent responses, indicating that cortex can express high-frequency drive when upstream relay is bypassed. In contrast, direct VPL activation produced strong thalamic responses but weak, onset-dominated high-frequency cortical responses, and tuned-burst stimulation showed temporal compression before cortical expression. DCM indicated preferential enhancement of VPL-to-S1FL effective connectivity at intermediate frequencies. These findings identify a frequency-dependent bottleneck in VPL-to-S1FL transfer, rather than local cortical responsiveness, as a constraint on sustained cortical expression of temporally dense sensory input.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "Zijuan Yu",
      "orcid": "0009-0003-8483-0799"
    },
    {
      "name": "Haoyu Wang"
    },
    {
      "name": "Yan Zhuo"
    },
    {
      "name": "Zhentao Zuo",
      "orcid": "0000-0002-5909-3884"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8rx98x5b5kmnp.bib",
  "cited_by": 0,
  "doi": "10.1016/j.isci.2026.118035",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13734801/",
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  "language": "en",
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  "licence_label": "CC BY-NC 4.0",
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  "native_subjects": [
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      "heading",
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      "heading",
      "Neuroscience"
    ],
    [
      "heading",
      "Sensory neuroscience"
    ],
    [
      "heading",
      "Systems neuroscience"
    ],
    [
      "openalex",
      "2805|Neural dynamics and brain function"
    ]
  ],
  "openalex": "W7223666651",
  "pdf_url": null,
  "pmcid": "PMC13734801",
  "pmid": "42990577",
  "published": "2026-10-26",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/8rx98x5b5kmnp.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:16Z",
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      "url": "https://linkinghub.elsevier.com/retrieve/pii/S2589004226034188"
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      "first_seen": "2026-11-09T12:20:37Z",
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      "url": "https://doi.org/10.1016/j.isci.2026.118035"
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  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "heading:Neuroscience",
      "subfield": "neuroscience"
    }
  ],
  "title": "Frequency-dependent thalamocortical transfer limits sustained cortical expression of sensory drive",
  "title_text": "Frequency-dependent thalamocortical transfer limits sustained cortical expression of sensory drive",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:20:37Z",
  "url": "https://research.draconitic.com/paper/8rx98x5b5kmnp",
  "venue": "iScience",
  "versions": []
}