{
  "abstract": "Alyftrek (vanzacaftor/tezacaftor/deutivacaftor) was evaluated in cystic fibrosis (CF) airway models. S-vanzacaftor showed high potency, restoring F508del-CFTR function at nanomolar concentrations, enhanced by tezacaftor. Deutivacaftor matched ivacaftor efficacy in triple combinations. Both regimens improved CFTR maturation. The R-enantiomer was less effective and antagonistic. Notably, reduced doses retained substantial activity, supporting lower dosing strategies. These findings highlight S-vanzacaftor potency and validate deutivacaftor as an effective potentiator in CF therapy.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "name": "Sandra Mirval"
    },
    {
      "name": "Louise Damy"
    },
    {
      "name": "Auguste Sauvage de Gérando"
    },
    {
      "name": "Christine Barrault"
    },
    {
      "name": "Isabelle Fixe"
    },
    {
      "name": "Édouard Sage"
    },
    {
      "name": "Christelle Coraux"
    },
    {
      "name": "Benjamin Simonneau"
    },
    {
      "name": "Benedicte Duriez"
    },
    {
      "name": "Pascale Fanen"
    },
    {
      "name": "Anne Cantereau"
    },
    {
      "name": "Clarisse Vandebrouck"
    },
    {
      "name": "Frederic Becq"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8s28yv6b7th0b.bib",
  "cited_by": 0,
  "doi": "10.1152/ajplung.00103.2026",
  "fulltext_url": null,
  "id": "8s28yv6b7th0b",
  "issns": [
    "1040-0605",
    "1522-1504"
  ],
  "landing_url": "https://univ-reims.hal.science/hal-05743413v1",
  "language": "en",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "2740|Cystic Fibrosis Research Advances"
    ]
  ],
  "openalex": "W7203741362",
  "pdf_url": null,
  "pmcid": null,
  "pmid": "42616613",
  "published": "2026-08-19",
  "publisher": "American Physiological Society",
  "ris": "https://research.draconitic.com/paper/8s28yv6b7th0b.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:31Z",
      "native_id": "hal-05743413",
      "source": "hal",
      "url": "https://univ-reims.hal.science/hal-05743413v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    }
  ],
  "title": "Functional and biochemical characterization of Alyftrek® components reveals high-potency rescue of F508del-CFTR",
  "title_text": "Functional and biochemical characterization of Alyftrek® components reveals high-potency rescue of F508del-CFTR",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:31Z",
  "url": "https://research.draconitic.com/paper/8s28yv6b7th0b",
  "venue": "American Journal of Physiology - Lung Cellular and Molecular Physiology",
  "versions": []
}