{
  "abstract": "Infants are vulnerable to meningococcal disease. In this open-label phase III study (NCT03632720; registered 13/8/2018), infants were randomised to quadrivalent ACWY conjugated vaccine, MenACYW-TT, at 3 and 12–13 months and four-component meningococcus group B vaccine (4CMenB) at 2, 4, and 12–13 months (Group 1), MenACYW-TT at 3 and 12–13 months and 4CMenB at 2 and 4 months (Group 2), or 4CMenB at 2, 4, and 12–13 months (Group 3). Routine vaccines were also administered per UK schedule. Primary outcome of non-inferiority of seroprotection rates against the four capsular groups (A, C, W, and Y) in Group 1 versus Group 2 at day 30 after the second vaccine dose was demonstrated with seroprotection rates ≥99% against all capsular groups in both groups. In Group 3, cross-reactivity was observed, with hSBA titres against capsular groups A and C increasing >10-fold after the third 4CMenB dose. Reactogenicity was consistent with the known profiles of both vaccines; one case of anaphylaxis related to MenACYW-TT was reported and resolved without sequelae. No new safety concerns were identified.",
  "abstract_shown": true,
  "affiliations": [
    "Global Clinical Development Strategy, Sanofi",
    "Bristol Vaccine Centre, Schools of Population Health Sciences and Cellular and Molecular Medicine, University of Bristol and Bristol Royal Hospital for Children, University Hospitals Bristol NHS Foundation Trust",
    "Rame Medical Limited, Penntorr Health",
    "Mounts Bay Medical Ltd, Connor Downs Surgery, Connor Downs, Hayle",
    "National Institute for Health Research Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, and Faculty of Medicine and Institute for Life Sciences, University of Southampton",
    "Vaccine Institute, City St George’s, University of London",
    "Department of Paediatrics, Yeovil District Hospital, Yeovil",
    "Newquay Health Centre, Newquay",
    "Royal United Hospital, Combe Park, Bath",
    "Royal Devon University Hospital",
    "The Adam Practice, Poole",
    "Royal Manchester Children’s Hospital, Manchester University NHS Foundation Trust, and Division of Immunology, Immunity to Infection and Respiratory Medicine, University of Manchester",
    "Chaddlewood Surgery, Plympton",
    "Vaccine Evaluation Unit, UK Health Security Agency",
    "Global Clinical Immunology, Sanofi",
    "Global Pharmacovigilance-Vaccines, IQVIA; and Patient Safety & Pharmacovigilance, Sanofi",
    "Global Clinical Operations, Sanofi",
    "Evidence Generation and Decision Sciences, Sanofi",
    "Patient Safety and Pharmacovigilance, Sanofi R&D"
  ],
  "article_type": null,
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  "author_total": 23,
  "authors": [
    {
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        0
      ],
      "name": "Monica A. McArthur"
    },
    {
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        1
      ],
      "name": "Adam Finn"
    },
    {
      "affs": [
        2
      ],
      "name": "Lawrence Barnes"
    },
    {
      "affs": [
        3
      ],
      "name": "Richard Burkimsher"
    },
    {
      "affs": [
        4
      ],
      "name": "Katrina Cathie"
    },
    {
      "affs": [
        5
      ],
      "name": "Eva Galiza"
    },
    {
      "affs": [
        6
      ],
      "name": "Paul Heaton"
    },
    {
      "affs": [
        7
      ],
      "name": "Nicholas Jacobsen"
    },
    {
      "affs": [
        8
      ],
      "name": "Stephen Jones"
    },
    {
      "affs": [
        9
      ],
      "name": "Sian Ludman"
    },
    {
      "affs": [
        10
      ],
      "name": "Patrick Moore"
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    {
      "affs": [
        11
      ],
      "name": "Clare Murray"
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    {
      "affs": [
        4
      ],
      "name": "Daniel Owens"
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    {
      "affs": [
        12
      ],
      "name": "Alexander Trotman"
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    {
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        13
      ],
      "name": "Ray Borrow"
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    {
      "affs": [
        14
      ],
      "name": "Julie Chaix"
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    {
      "affs": [
        15
      ],
      "name": "Arlette Delgado"
    },
    {
      "affs": [
        16
      ],
      "name": "Estelle Dubois"
    },
    {
      "affs": [
        17
      ],
      "name": "Youjun Huang"
    },
    {
      "affs": [
        18
      ],
      "name": "Olga Syrkina"
    },
    {
      "affs": [
        0
      ],
      "name": "Betzana Zambrano"
    },
    {
      "affs": [
        0
      ],
      "name": "Mandeep Singh Dhingra"
    },
    {
      "affs": [
        0
      ],
      "name": "Christine Rehm"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8sexzrzjpqq0s.bib",
  "cited_by": 0,
  "doi": "10.1038/s41541-026-01508-7",
  "fulltext_url": "https://doi.org/10.1038/s41541-026-01508-7",
  "id": "8sexzrzjpqq0s",
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  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC254-282"
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    [
      "lcc",
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      "openalex",
      "2404|Bacterial Infections and Vaccines"
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  "pdf_url": "https://www.nature.com/articles/s41541-026-01508-7_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-01",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/8sexzrzjpqq0s.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:45:35Z",
      "native_id": "7aeb08d1b3d540e1a290c75f2e138e4d",
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  "subjects": [
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      "field": "biology",
      "origin": "openalex:2404|Bacterial Infections and Vaccines",
      "subfield": "microbiology"
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  ],
  "title": "Safety and immunogenicity of concomitant quadrivalent meningococcus ACYW-TT and meningococcus group B vaccines",
  "title_text": "Safety and immunogenicity of concomitant quadrivalent meningococcus ACYW-TT and meningococcus group B vaccines",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:35Z",
  "url": "https://research.draconitic.com/paper/8sexzrzjpqq0s",
  "venue": "npj Vaccines",
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}