{
  "abstract": "Introduction\n\nCadmium (Cd) toxicity is one of the major public health problems because of its long half-life (10-30 years). Exposure to Cd can cause toxicity that affects several organs, including the liver and the kidney. Saroglitazar is highlighted in this study as a potential preventative medication against hepatic-renal damage induced by Cd in rats.Methods\n\nCd (3 mg/kg) was injected for five successive days to induce hepatic and renal damage. Saroglitazar (2 and 4 mg/kg/day) was given orally for five successive days concurrently with Cd.Results\n\nSaroglitazar effectively improved hepatic and renal function and structure. In the meantime, saroglitazar mitigated the oxidative stress caused by Cd; it increased the level of reduced glutathione (GSH) and the activity of superoxide dismutase (SOD) and decreased malondialdehyde (MDA) content. Saroglitazar-treated groups showed a significant reduction in hepatic and renal nuclear factor kappa B (NF-κB), tumor necrosis factor (TNF)-α, and interleukin-6 (IL-6). Furthermore, saroglitazar pretreatment significantly increased nuclear factor erythroid 2-related factor 2 (Nrf2); furthermore, there was a marked reduction in the expression of caspase-3 in both hepatic and renal tissues.Conclusion\n\nCollectively, saroglitazar showed a protective effect against Cd-induced hepatorenal injury in rats.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ahmed Alanazi"
    },
    {
      "affs": [
        0
      ],
      "name": "Hoda E Kafl"
    },
    {
      "affs": [
        0
      ],
      "name": "Dalia H El-Kashef"
    },
    {
      "affs": [
        0
      ],
      "name": "Ghada M Suddek"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8t6atvgsysyy8.bib",
  "cited_by": 0,
  "doi": "10.3389/fphar.2026.1916439",
  "fulltext_url": "https://europepmc.org/articles/PMC13677922",
  "id": "8t6atvgsysyy8",
  "issns": [
    "1663-9812"
  ],
  "landing_url": "https://europepmc.org/article/MED/42898561",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2307|Heavy Metal Exposure and Toxicity"
    ]
  ],
  "openalex": "W7220403101",
  "pdf_url": "https://europepmc.org/articles/PMC13677922?pdf=render",
  "pmcid": "PMC13677922",
  "pmid": "42898561",
  "published": "2026-10-05",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/8t6atvgsysyy8.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:37Z",
      "native_id": "MED:42898561",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42898561"
    },
    {
      "first_seen": "2026-10-30T12:20:06Z",
      "native_id": "10.3389/fphar.2026.1916439",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1916439/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2307|Heavy Metal Exposure and Toxicity",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Saroglitazar protects against cadmium-induced hepatorenal injury in rats by suppressing NF-κB and upregulating Nrf2.",
  "title_text": "Saroglitazar protects against cadmium-induced hepatorenal injury in rats by suppressing NF-κB and upregulating Nrf2.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:06Z",
  "url": "https://research.draconitic.com/paper/8t6atvgsysyy8",
  "venue": "Frontiers in pharmacology",
  "versions": []
}