{
  "abstract": "S-palmitoylation is a reversible lipid modification that can alter protein localization, stability, interactions and signaling, but detection of a modified cysteine does not establish its functional importance. Post-translational Modification-Palmoylation Pipeline(PTM-PAL) is a web-accessible workflow for prioritizing candidate S-palmitoylation sites and modification configurations for functional follow-up. It integrates site-specific evolutionary context and UniProt annotation, paired wild-type and palmitoylated structural models, local protein-body solvent-accessible surface-area remodeling, and membrane-embedding descriptors. The workflow takes site metadata, full-length sequences and paired WT/PAL structural models as input and returns dimension-resolved outputs together with a within-protein score on a 0-10 scale. Single-site and dual-site configurations can be examined separately, while the underlying measurements remain available for inspection. PTM-PAL is intended to organize heterogeneous biochemical, structural and membrane-related evidence into testable priorities; the score is not a calibrated probability and does not replace biochemical or functional validation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Nutrition and Food Hygiene, School of Public Health, Institute of Nutrition, Fudan University, Shanghai 200032, China.",
    "Department of Good Clinical Practice, Medical Guarantee Center, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China.",
    "Independent Researcher, Shanghai 201210, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xin-Yu Bi"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jia-Ni Chen"
    },
    {
      "affs": [
        2
      ],
      "name": "Xiong-Fei Pan"
    },
    {
      "affs": [
        0
      ],
      "name": "Ling Tao",
      "orcid": "0000-0002-4139-2894"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8t93cq5ejcsgy.bib",
  "cited_by": 0,
  "doi": "10.3390/membranes16100341",
  "fulltext_url": "https://europepmc.org/articles/PMC13707211",
  "id": "8t93cq5ejcsgy",
  "issns": [
    "2077-0375"
  ],
  "landing_url": "https://europepmc.org/article/MED/42931019",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Protein Structure and Dynamics"
    ]
  ],
  "openalex": "W7221804584",
  "pdf_url": "https://europepmc.org/articles/PMC13707211?pdf=render",
  "pmcid": "PMC13707211",
  "pmid": "42931019",
  "published": "2026-10-14",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/8t93cq5ejcsgy.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:01Z",
      "native_id": "MED:42931019",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42931019"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Protein Structure and Dynamics",
      "subfield": "molecular-biology"
    }
  ],
  "title": "PTM-PAL Pipeline: A Python Web Platform of Integrative Scoring System for Assessing the Functional Impact of Protein S-Palmitoylation.",
  "title_text": "PTM-PAL Pipeline: A Python Web Platform of Integrative Scoring System for Assessing the Functional Impact of Protein S-Palmitoylation.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:01Z",
  "url": "https://research.draconitic.com/paper/8t93cq5ejcsgy",
  "venue": "Membranes",
  "versions": []
}