{
  "abstract": "Background: Endometriosis has a substantial immune component, but the cellular contexts of genetically regulated disease susceptibility remain incompletely resolved.\n\nMethods: We tested single-cell cis-eQTL instruments from 20 OneK1K peripheral-blood cell types against FinnGen R12 endometriosis (20,190 cases; 130,160 controls) using single-variant Mendelian randomization (MR), colocalization and sensitivity analyses. Benjamini–Yekutieli (BY) correction distinguished conservative findings from an exploratory Benjamini–Hochberg (BH) screen. Directional consistency, bulk-blood MR and lesion expression provided contextual comparisons.\n\nResults: Across 9157 unique gene–cell-type tests, 135 associations in 61 genes reached BH-FDR < 0.05. Colocalization at the default prior prioritized 10 genes (6 protein-coding) across 28 pairs. LOC102723878 and RUVBL1 were also BY-robust; IGF1R in natural killer (NK) cells was BH-supported but not BY-robust (PP4 = 0.89; OR 1.11 per SD higher expression). Its NK attribution reflects instrument availability and does not establish exclusivity. Colocalization was prior-sensitive. Directional concordance in a partly overlapping sample (8/8) was descriptive. Bulk-blood MR nominated 3/6 testable protein-coding genes. IGF1R lesion expression showed a nonsignificant upward trend (P = 0.101).\n\nConclusion: The analysis prioritizes immune-context candidate genes for functional study. IGF1R remains an exploratory, mechanistically unresolved nomination. Genetic support and protein tractability do not establish therapeutic benefit or reproductive safety; experimental validation is required.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Urology, The Second People’s Hospital of Wuhu, Wuhu, Anhui, People’s Republic of China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xin Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Guanglei Yao"
    },
    {
      "affs": [
        0
      ],
      "name": "Wei Ding",
      "orcid": "0009-0009-6010-6783"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8tbchakgv0yc3.bib",
  "cited_by": 0,
  "doi": "10.2147/ijwh.s643362",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13730072/",
  "id": "8tbchakgv0yc3",
  "issns": [
    "1179-1411"
  ],
  "landing_url": "https://doi.org/10.2147/ijwh.s643362",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2743|Endometriosis Research and Treatment"
    ]
  ],
  "openalex": "W7224433167",
  "pdf_url": "https://www.dovepress.com/article/download/121577",
  "pmcid": "PMC13730072",
  "pmid": "42979209",
  "published": "2026-10-30",
  "publisher": "Dove Press",
  "ris": "https://research.draconitic.com/paper/8tbchakgv0yc3.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:22:43Z",
      "native_id": "PMC13730072",
      "source": "pmc",
      "url": "https://doi.org/10.2147/ijwh.s643362"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2743|Endometriosis Research and Treatment",
      "subfield": "reproductive-child"
    }
  ],
  "title": "Single-Cell Immune Cis-eQTL Mendelian Randomization Prioritizes Cell-Type-Resolved Candidate Causal Genes for Endometriosis",
  "title_text": "Single-Cell Immune Cis-eQTL Mendelian Randomization Prioritizes Cell-Type-Resolved Candidate Causal Genes for Endometriosis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:22:43Z",
  "url": "https://research.draconitic.com/paper/8tbchakgv0yc3",
  "venue": "International Journal of Women's Health",
  "versions": []
}