{
  "abstract": "Purpose: To assess whether elexacaftor–tezacaftor–ivacaftor (ETI) therapy improves bronchiectasis in cystic fibrosis at CT and to identify associated factors. Materials and Methods: This retrospective study included consecutive patients with cystic fibrosis (CF) from two reference centers (between January 2020 and January 2025). Pulmonary function testing was performed, including forced expiratory volume in 1 second as percentage predicted (FEV1%p), and CT was performed at three time points: 2 years before ETI (Y-2), at initiation of ETI (Y0), and 1 year after ETI (Y1). Bronchiectasis was assessed quantitatively and visually for shape and regional extent. Comparisons of paired medians were done using the Friedman test. Results: A total of 106 patients were included (median age, 19 years [IQR, 12–29]; 59 male patients; median FEV1%p, 80% [IQR, 55–99]). Of these 106 patients, 101 (95.3%) had mild-to-moderate disease severity, with FEV1%p greater than 40%. Bronchiectasis normalized volumes increased between Y-2 (7.6 [IQR, 2–19]) and Y0 (15.3 [IQR, 5.6–32]) but decreased at Y1 (3.6 [IQR, 0.6–25]; P < .001). Bronchiectasis improved in 74 of 106 patients (69.8%), including 18 of 106 (16.9%) with complete resolution and 56 of 106 (52.9%) with partial reduction, with a median volume reduction of 64% and six resolved segments per patient. Bronchiectasis improvement was associated with younger age (P < .001), cylindric CT pattern (P < .001), fewer CT abnormalities (P < .001), and greater FEV1%p increase (P = .03). Younger age, lower Pseudomonas aeruginosa colonization, and lower CT mucus volume were independent predictors of bronchiectasis improvement (R2 = 0.50; P < .001). Conclusion: Bronchiectasis improvement occurred after ETI treatment in a substantial fraction of patients with predominantly mild-to-moderate CF. Improvement was linked to younger age and better disease status at ETI initiation, supporting early intervention",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "Amel Imene Hadj Bouzid"
    },
    {
      "name": "Daphné Pasche"
    },
    {
      "name": "Ilyes Benlala"
    },
    {
      "name": "Stéphanie Bui"
    },
    {
      "name": "Julie Macey"
    },
    {
      "name": "Jean Delmas"
    },
    {
      "name": "Fabien Beaufils"
    },
    {
      "name": "Baudouin Denis de Senneville"
    },
    {
      "name": "Patrick Berger"
    },
    {
      "name": "Gaël Dournes"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8tn3qqvh7fagp.bib",
  "cited_by": 2,
  "doi": "10.1148/ryct.250116",
  "fulltext_url": null,
  "id": "8tn3qqvh7fagp",
  "issns": [
    "2638-6135"
  ],
  "landing_url": "https://hal.science/hal-05805896v1",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.mhep"
    ],
    [
      "hal",
      "1.sdv.sp"
    ],
    [
      "hal",
      "1.sdv.spee"
    ],
    [
      "hal",
      "2.sdv.mhep.psr"
    ],
    [
      "hal",
      "2.sdv.sp.pharma"
    ],
    [
      "openalex",
      "2740|Cystic Fibrosis Research Advances"
    ]
  ],
  "openalex": "W4416419874",
  "pdf_url": "https://hal.science/hal-05805896/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-20",
  "publisher": "Radiological Society of North America",
  "ris": "https://research.draconitic.com/paper/8tn3qqvh7fagp.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:59Z",
      "native_id": "hal-05805896",
      "source": "hal",
      "url": "https://hal.science/hal-05805896v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    },
    {
      "field": "medicine",
      "origin": "hal:1.sdv.spee",
      "subfield": "epidemiology-public-health"
    },
    {
      "field": "medicine",
      "origin": "hal:1.sdv.sp",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Quantitative CT Evaluation of Bronchiectasis Improvement in Cystic Fibrosis after CFTR-Modulator Therapy",
  "title_text": "Quantitative CT Evaluation of Bronchiectasis Improvement in Cystic Fibrosis after CFTR-Modulator Therapy",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:59Z",
  "url": "https://research.draconitic.com/paper/8tn3qqvh7fagp",
  "venue": "Radiology: Cardiothoracic Imaging",
  "versions": []
}