{
  "abstract": "Genome-wide association studies (GWAS) identify loci associated with human diseases and disease-related traits, but the regulators and cellular contexts linked to these signals remain difficult to resolve. We present scTraitReg, a database of trait-relevant transcription factor (TF) eRegulons—TFs with their target genes and linked cis-regulatory regions—at single-cell resolution. scTraitReg integrates 655 sets of curated GWAS summary statistics covering 122 Medical Subject Headings (MeSH) disease terms with 111 human single-cell multi-omic datasets profiling RNA and chromatin accessibility in the same cells. The resource spans 34 tissues, 252 cell types, 2 081 538 cells, and 2208 curated GWAS—single-cell analysis pairs. Across these analyses, it contains 2 840 939 TF–cell-type records for 886 regulators; 67 666 records met all three criteria—cell-type specificity, genetic relevance, and the trait-associated regulon score—and were included as candidate trait-relevant eRegulon records. Each record links to the TF—target regulatory network with its cis-regulatory regions, cell-type-resolved evidence, per-cell regulon module scores, and target-gene enrichment, all available as downloadable tables. Users can search by disease, tissue, cell type, or regulator and examine these associations through interactive visualizations. scTraitReg thus provides a searchable and reusable resource linking genetic associations to cell-type-specific regulatory programs, and is freely available at https://www.sctraitreg.bio/.",
  "abstract_shown": true,
  "affiliations": [
    "Jiangsu Key Laboratory for Biomedical Electromagnetic Precision Theranostics, School of Biomedical Engineering and Informatics, Nanjing Medical University , Nanjing, Jiangsu 211166 ,",
    "Department of Transfusion Medicine, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing , Jiangsu 210022 ,",
    "Clinical Medical Research Center, Children’s Hospital of Nanjing Medical University , Nanjing, Jiangsu 210008 ,",
    "Cardiovascular Center, The Second Affiliated Hospital of Nanjing Medical University , Nanjing, Jiangsu 210011 ,"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Haoran Chen",
      "orcid": "0000-0002-1666-3226"
    },
    {
      "affs": [
        0
      ],
      "name": "Yin Liu"
    },
    {
      "affs": [
        1
      ],
      "name": "Xue Rui"
    },
    {
      "affs": [
        0
      ],
      "name": "Shengxian Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Lingna Sun"
    },
    {
      "affs": [
        0
      ],
      "name": "Guoli Xiao"
    },
    {
      "affs": [
        0
      ],
      "name": "Haozhe Tang"
    },
    {
      "affs": [
        2
      ],
      "name": "Yanqun Sun"
    },
    {
      "affs": [
        3
      ],
      "name": "Xiang Guan",
      "orcid": "0009-0007-1251-5959"
    },
    {
      "affs": [
        0
      ],
      "name": "Chen Cao",
      "orcid": "0000-0001-5343-808X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8tz2zwm4bq7eb.bib",
  "cited_by": 0,
  "doi": "10.1093/nar/gkag1017",
  "fulltext_url": null,
  "id": "8tz2zwm4bq7eb",
  "issns": [
    "0305-1048",
    "1362-4962"
  ],
  "landing_url": "https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkag1017/8971830",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Genomics and Chromatin Dynamics"
    ]
  ],
  "openalex": "W7223182884",
  "pdf_url": "https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkag1017/72302042/gkag1017.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-22",
  "publisher": "Oxford University Press (OUP)",
  "ris": "https://research.draconitic.com/paper/8tz2zwm4bq7eb.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:50Z",
      "native_id": "10.1093/nar/gkag1017",
      "source": "crossref",
      "url": "https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkag1017/8971830"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Genomics and Chromatin Dynamics",
      "subfield": "molecular-biology"
    }
  ],
  "title": "scTraitReg: a single-cell multi-omic database of trait-relevant transcription factor eRegulons",
  "title_text": "scTraitReg: a single-cell multi-omic database of trait-relevant transcription factor eRegulons",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:50Z",
  "url": "https://research.draconitic.com/paper/8tz2zwm4bq7eb",
  "venue": "Nucleic Acids Research",
  "versions": []
}