{
  "abstract": "Background: Respiratory tract infections range from asymptomatic colonisation to an invasive disease. Recent studies suggest that nasopharyngeal microbiota may influence this variability. Emerging evidence points to Dolosigranulum pigrum, a nasopharyngeal commensal, as a potentially protective bacterium. This study aimed to identify variables associated with the presence of D. pigrum in the nasopharynx of children with varying respiratory health statuses. Methods: Nasopharyngeal aspirates were collected from children <18 years who were asymptomatic (n = 65), had banal viral infection (n = 48), or Invasive Pneumococcal Disease (IPD) (n = 27). The presence of D. pigrum was defined as >0.1% of total sequences obtained by 16S rRNA gene sequencing. Variables included sex, breastfeeding, delivery mode, S. pneumoniae carriage, respiratory viruses and clinical features. Results: Among 140 children (73 males, 67 females), D. pigrum was detected in 79 (56.4%): 44/65 in the healthy group; 26/48 of viral and 9/27 IPD cases. Multivariate analysis revealed significant associations with health status and sex. Healthy children were more likely to carry D. pigrum than IPD cases (44/79 vs. 26/79; p = 0.028). Males were more frequently D. pigrum carriers than females (48/79 vs. 31/79; p = 0.033). Conclusion: D. Pigrum was associated with respiratory health, being more prevalent in healthy children, and showed potential sex-related differences.",
  "abstract_shown": true,
  "affiliations": [
    "Infectious Diseases and Microbiome Group, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Spain",
    "Hospital Sant Joan de Déu Barcelona, Esplugues de Llobregat, Spain",
    "CIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain",
    "Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Barcelona, Spain",
    "Faculty of Medicine, Universitat de Barcelona, Barcelona, Spain",
    "Genomics & Health Department, FISABIO Foundation, Valencia, Spain"
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Maria Cisneros"
    },
    {
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        1
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      "name": "Desirée Henares"
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    {
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        2
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      "name": "Aleix Lluansí"
    },
    {
      "affs": [
        3
      ],
      "name": "Pedro Brotons"
    },
    {
      "affs": [
        4
      ],
      "name": "Cristian Launes"
    },
    {
      "affs": [
        5
      ],
      "name": "Daniel Penela-Sanchez"
    },
    {
      "name": "Gerard Gonzalez-Comino"
    },
    {
      "name": "Amaresh Perez-Arguello"
    },
    {
      "name": "Mariona F. de Sevilla"
    },
    {
      "name": "Alex Mira"
    },
    {
      "name": "Miguel Blanco-Fuertes"
    },
    {
      "name": "Carmen Muñoz-Almagro"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8vbdmzy29be3z.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pone.0345189",
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  "id": "8vbdmzy29be3z",
  "issns": [
    "1932-6203"
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  "landing_url": "https://doi.org/10.1371/journal.pone.0345189",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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  "pmcid": null,
  "pmid": null,
  "published": "2026-09-02",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/8vbdmzy29be3z.ris",
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    {
      "first_seen": "2026-10-30T12:18:02Z",
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  "title": "Presence of Dolosigranulum pigrum in the nasopharynx and its relationship with respiratory health status in paediatric population",
  "title_text": "Presence of Dolosigranulum pigrum in the nasopharynx and its relationship with respiratory health status in paediatric population",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:02Z",
  "url": "https://research.draconitic.com/paper/8vbdmzy29be3z",
  "venue": "PLOS One",
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}