{
  "abstract": "assays and provide a concise framework for prioritizing and mapping them to decision stages. We also discuss the main factors affecting degrader's cellular performance and principles that have emerged to guide drug design.",
  "abstract_shown": true,
  "affiliations": [
    "Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, Dundee DD1 5JJ, U.K"
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  "article_type": "review",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
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      "name": "Charlotte Crowe",
      "orcid": "0000-0003-2068-8255"
    },
    {
      "affs": [
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      "name": "Alessio Ciulli",
      "orcid": "0000-0002-8654-1670"
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  ],
  "bibtex": "https://research.draconitic.com/paper/8vbga2phegyjn.bib",
  "cited_by": 6,
  "doi": "10.1021/acs.chemrev.5c00800",
  "fulltext_url": null,
  "id": "8vbga2phegyjn",
  "issns": [
    "0009-2665",
    "1520-6890"
  ],
  "landing_url": "https://doi.org/10.1021/acs.chemrev.5c00800",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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      "1312|Protein Degradation and Inhibitors"
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  "openalex": "W7161108236",
  "pdf_url": null,
  "pmcid": "PMC13220276",
  "pmid": "42133863",
  "published": "2026-05-14",
  "publisher": "American Chemical Society",
  "ris": "https://research.draconitic.com/paper/8vbga2phegyjn.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:26:48Z",
      "native_id": "W7161108236",
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      "url": "https://doi.org/10.1021/acs.chemrev.5c00800"
    }
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  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Protein Degradation and Inhibitors",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Methods to Study the Molecular Mechanism and Drive the Design of Protein Degraders",
  "title_text": "Methods to Study the Molecular Mechanism and Drive the Design of Protein Degraders",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T13:20:30Z",
  "url": "https://research.draconitic.com/paper/8vbga2phegyjn",
  "venue": "Chemical Reviews",
  "versions": []
}