{
  "abstract": "Background/objectives\n\nCreatine (Cr) supplementation may serve as a nutritional intervention, enhancing gut metabolism and preserving lean body mass, specifically fat-free mass, thereby improving functional capacity and quality of life in individuals with Crohn's disease (CD). This paper aims to explore the potential mechanisms through which Cr supplementation may influence CD patients and review the current literature on this topic.Results\n\nStudies were analyzed to assess the relationship between Cr supplementation and CD. Preliminary evidence suggests potential therapeutic benefits, although data remain limited.Discussion\n\nCr supplementation warrants further investigation through clinical trials and cohort studies. Emerging data from both in vitro and in vivo models indicate creatine monohydrate (CrM) may constitute a biologically reasonable supportive strategy, requiring formal evaluation in clinical trials in patients with CD.Conclusions\n\nAs a foundational step, further analysis of National Health and Nutrition Examination Survey (NHANES) data to document Cr-rich food sources and daily intake patterns is recommended before initiating clinical trials in Crohn's disease cohorts.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Nutritional Sciences and Dietetics, School of Health Sciences, International Hellenic University, 57001 Thessaloniki, Greece.",
    "Exercise & Sport Nutrition Lab, Human Clinical Research Facility, Department of Health & Kinesiology, Texas A&M University, College Station, TX 77843, USA.",
    "Laboratory of Hygiene and Environmental Protection, School of Medicine, Democritus University of Thrace, Dragana, 68100 Alexandroupolis, Greece.",
    "Department of Food Science and Nutrition, School of Environment, University of Aegean, 81100 Myrina, Greece."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Konstantinos Papadimitriou",
      "orcid": "0000-0002-0059-2873"
    },
    {
      "affs": [
        1
      ],
      "name": "Richard B Kreider",
      "orcid": "0000-0002-3906-1658"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Georgia-Eirini Deligiannidou",
      "orcid": "0000-0003-3976-4473"
    },
    {
      "affs": [
        3
      ],
      "name": "Constantinos Giaginis",
      "orcid": "0000-0003-2878-4831"
    },
    {
      "affs": [
        0
      ],
      "name": "Sousana K Papadopoulou",
      "orcid": "0000-0002-6408-6128"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8vj5081zew7s9.bib",
  "cited_by": 0,
  "doi": "10.3390/muscles5040071",
  "fulltext_url": "https://europepmc.org/articles/PMC13692481",
  "id": "8vj5081zew7s9",
  "issns": [
    "2813-0413"
  ],
  "landing_url": "https://europepmc.org/article/MED/42924643",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1307|Muscle metabolism and nutrition"
    ]
  ],
  "openalex": "W7220461612",
  "pdf_url": "https://europepmc.org/articles/PMC13692481?pdf=render",
  "pmcid": "PMC13692481",
  "pmid": "42924643",
  "published": "2026-10-04",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/8vj5081zew7s9.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:36Z",
      "native_id": "MED:42924643",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42924643"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1307|Muscle metabolism and nutrition",
      "subfield": "cell-biology"
    }
  ],
  "title": "Creatine Supplementation in Crohn's Disease: Possible Therapeutic Trends in Symptoms and Muscle Tissue Integrity.",
  "title_text": "Creatine Supplementation in Crohn's Disease: Possible Therapeutic Trends in Symptoms and Muscle Tissue Integrity.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:36Z",
  "url": "https://research.draconitic.com/paper/8vj5081zew7s9",
  "venue": "Muscles (Basel, Switzerland)",
  "versions": []
}