{
  "abstract": "Chromothripsis is a catastrophic chromosomal rearrangement found in ~40% of primary tumors, yet its landscape in cancer cell lines (CCLs) remains uncharacterized. To address this gap, we developed a pipeline to detect chromothripsis-like events from copy-number data alone, and mapped their occurrence across 1,646 human CCLs. Chromothripsis patterns were broadly conserved between primary tumors and CCLs, but CCLs displayed some distinct features and a significantly higher prevalence of chromothripsis. Chromothripsis continued to emerge during culture propagation, likely contributing to its increased prevalence in CCLs. Integrating genomic and functional data revealed selective vulnerabilities: chromothriptic cells were resistant to DNA damage-inducing agents but highly sensitive to histone deacetylase inhibitors (HDACi). Using isogenic models, we validated that HDACi could synergistically sensitize chromothriptic cells to DNA damage-inducing agents. Our study establishes the first comprehensive resource of chromothripsis in CCLs and reveals functional consequences and therapeutic vulnerabilities of chromothripsis-positive cancers.",
  "abstract_shown": true,
  "affiliations": [
    "Tel Aviv University"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "G. Leor"
    },
    {
      "name": "T. Ben-Yishay"
    },
    {
      "name": "A. Tarrab"
    },
    {
      "name": "Y. Eliezer"
    },
    {
      "name": "T. Winkler"
    },
    {
      "name": "M. Goetz"
    },
    {
      "name": "L. Raz"
    },
    {
      "name": "E. Reuveni"
    },
    {
      "name": "R. Shamir"
    },
    {
      "affs": [
        0
      ],
      "name": "U. Ben-David"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8vn6em6ss9q7g.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.30.763015",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.30.763015v1.full",
  "id": "8vn6em6ss9q7g",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.30.763015v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "cancer biology"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.30.763015v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-30",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/8vn6em6ss9q7g.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:21:12Z",
      "native_id": "10.64898/2026.10.30.763015",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.30.763015v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "biorxiv:cancer biology",
      "subfield": "oncology"
    }
  ],
  "title": "Mapping chromothripsis across human cancer cell lines reveals genome evolution and therapeutic vulnerabilities",
  "title_text": "Mapping chromothripsis across human cancer cell lines reveals genome evolution and therapeutic vulnerabilities",
  "type": "preprint",
  "updated_at": "2026-11-01T00:21:12Z",
  "url": "https://research.draconitic.com/paper/8vn6em6ss9q7g",
  "venue": "bioRxiv",
  "versions": []
}