{
  "abstract": "Objective: To examine whether continuous impulse oscillometry (IOS)-derived respiratory mechanical measures are associated with subsequent fibrotic disease progression in interstitial lung disease (ILD).\n\nMethods: In this single-center ambispective cohort study, 255 adults with fibrotic ILD underwent baseline spirometry, diffusing capacity testing and IOS. Fibrotic disease progression was defined using a PPF-like composite requiring at least two of three domains (worsening respiratory symptoms, physiological progression and radiological progression) within a 9–15-month assessment window. All IOS parameters were analyzed continuously using Firth penalized logistic regression, adjusted for age, sex, height and baseline FVC % predicted. X5 was additionally assessed using continuous scaling and restricted cubic splines. ROC analyses, non-IPF sensitivity analyses, and bootstrap validation were exploratory.\n\nResults: Fibrotic disease progression occurred in 41 of 255 patients (16.1%). A 1-SD worsening in X5 was associated with higher odds of progression (OR 8.89, 95% CI 4.66–19.47; P<0.001), as were AX (OR 1.67, 95% CI 1.22–2.38; P = 0.001) and Fres (OR 1.61, 95% CI 1.11–2.36; P = 0.012). Each 0.01 kPa·s/L increase in X5 was associated with lower odds of progression (adjusted OR 0.67, 95% CI 0.59–0.76; P<0.001), and the X5–progression association was nonlinear (P for nonlinearity<0.001). After exclusion of IPF, X5 and AX remained associated with progression. Bootstrap validation showed improved discrimination after adding AX or X5, but did not constitute external validation.\n\nConclusions: Continuous IOS measures, particularly X5 and AX, were associated with subsequent fibrotic disease progression in this single-center ILD cohort, with a weaker signal for Fres. The X5 association was nonlinear and remained evident after exclusion of IPF. ROC-derived thresholds were unstable and should be considered exploratory. These findings support further evaluation of oscillometric respiratory-mechanical abnormalities in larger externally validated cohorts but do not establish clinically applicable predictive thresholds.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Respiratory and Critical Care Medicine, the Affiliated Hospital of Xuzhou Medical University , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Chuhan Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yiying Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhen Feng"
    },
    {
      "affs": [
        0
      ],
      "name": "Yitian Sun"
    },
    {
      "affs": [
        0
      ],
      "name": "Maowei Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yanan Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Bi Chen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8w2cmj3z63yz4.bib",
  "cited_by": 0,
  "doi": "10.3389/fphys.2026.1962001",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13724450/?tool=EBI",
  "id": "8w2cmj3z63yz4",
  "issns": [
    "1664-042X"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13724450",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2740|Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis"
    ]
  ],
  "openalex": "W7222982721",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13724450/pdf/?tool=EBI",
  "pmcid": "PMC13724450",
  "pmid": "42973538",
  "published": "2026-10-19",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/8w2cmj3z63yz4.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T15:20:51Z",
      "native_id": "PMC:PMC13724450",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13724450"
    },
    {
      "first_seen": "2026-11-04T12:23:01Z",
      "native_id": "PMC13724450",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fphys.2026.1962001"
    },
    {
      "first_seen": "2026-11-04T15:20:48Z",
      "native_id": "MED:42973538",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42973538"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis",
      "subfield": "general"
    }
  ],
  "title": "Impulse oscillometry-derived respiratory mechanical abnormalities and fibrotic disease progression in interstitial lung disease: a single-center cohort study",
  "title_text": "Impulse oscillometry-derived respiratory mechanical abnormalities and fibrotic disease progression in interstitial lung disease: a single-center cohort study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:20:56Z",
  "url": "https://research.draconitic.com/paper/8w2cmj3z63yz4",
  "venue": "Frontiers in physiology",
  "versions": []
}