{ "abstract": "Tragopogon coelesyriacus is a traditional herbal medicine used for gastrointestinal disorders, mediated by its phytoconstituents. This study explores acute toxicity and gastroprotective potency of methanolic extracts of Tragopogon coelesyriacus (METC) in rats. Rats were aligned in 5 groups and pretreated with either normal saline, lansoprazole, or METC (200 and 400 mg/kg) before 5 mL/kg ethanol-induced gastric ulceration. The two-week toxicity study for METC (2 and 5 g/kg) showed no physiological alterations, behavioral changes, or morbidity in rats. Pretreatment with METC (200 and 400 mg/kg) improved gastric defense factors (mucus secretion and total stomach acidity), limiting mucosal penetrations and the lesioned areas. The histopathological results showed that METC (200 and 400 mg/kg) suppressed ethanol-induced gastric tissue alterations, indicated by increased gastric protective percentages (51.02% and 65.67%), less submucosal edema, epithelial exfoliation, lower mucous metaplasia, and necrotic areas. METC supplementation (200 and 400 mg/kg) restored the level of superoxide dismutase and catalase, while reducing the MDA by 29.84% and 48.64%, respectively. This was parallel with the anti-inflammatory effects of METC (200 and 400 mg/kg), decreasing TNF-α by 34.59%, 47.36%; IL-6 by 24.95%, 30.32%, and increasing IL-10 by 73.94%, 179.92%, respectively, relative to ulcer controls. Additionally, METC (200 and 400 mg/kg) remarkably modulated apoptotic proteins, lowering Bax by 31.10% and 45.50%, and increasing HSP 70 by 28.12 and 65.5%, respectively. The outcomes highlight the significant gastroprotective potential of Tragopogon coelesyriacus, which was mainly associated with its antioxidant, anti-inflammatory, and anti-apoptosis properties, making it a viable source for gastric ulcer management.", "abstract_shown": true, "affiliations": [ "Department of Chemistry, College of Science, University of Jeddah, Jeddah, Saudi Arabia", "Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan", "Department of Community Health Nursing, Cihan University-Erbil, Erbil, Iraq", "Department of Medical Laboratory Technology, Erbil Technical Health and Medical College, Erbil Polytechnic University, Erbil, Iraq", "Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia", "Department of Medical and Clinical Laboratory Technology, Faculty of Allied Medical Sciences, Applied Science Private University, Amman, Jordan", "Department of Biomedical Sciences, College of Health Sciences, Abu Dhabi University, Abu Dhabi, United Arab Emirates" ], "article_type": "Research Article", "arxiv": null, "author_total": 10, "authors": [ { "affs": [ 0 ], "name": "Hanan Ibrahim Alsharif" }, { "affs": [ 1 ], "name": "Mohammad Khaled Abu-Sini" }, { "affs": [ 2 ], "name": "Abdulrahman Ismael" }, { "affs": [ 3 ], "name": "Naz Farhad Abdulqadir" }, { "affs": [ 4 ], "name": "Gharieb S. El-Sayyad" }, { "affs": [ 5 ], "name": "Ahmed A.J. Jabbar" }, { "affs": [ 6 ], "name": "Sara Basil Abu Jalboush" }, { "name": "Rawan Fahad Mosallam Almehmadi" }, { "name": "Talal Salem Al-Qaisi" }, { "name": "Khalid M. Alqaisi" } ], "bibtex": "https://research.draconitic.com/paper/8wbxk5hskrkdj.bib", "cited_by": 0, "doi": "10.1371/journal.pone.0355381", "fulltext_url": null, "id": "8wbxk5hskrkdj", "issns": [ "1932-6203" ], "landing_url": "https://doi.org/10.1371/journal.pone.0355381", "language": null, "licence": "CC-BY-4.0", "licence_label": "CC BY 4.0", "licence_source": "journal", "licence_url": "https://creativecommons.org/licenses/by/4.0/", "metadata_licence": null, "native_subjects": [ [ "openalex", "1110|Medicinal Plant Research" ], [ "plos", "/Biology and life sciences/Anatomy/Digestive system/Gastrointestinal tract/Stomach" ], [ "plos", "/Biology and life sciences/Biochemistry/Antioxidants" ], [ "plos", "/Biology and life sciences/Cell biology/Cell processes/Cell death/Apoptosis" ], [ "plos", "/Biology and life sciences/Immunology/Immune response/Inflammation" ], [ "plos", "/Biology and life sciences/Toxicology/Toxicity" ], [ "plos", "/Medicine and health sciences/Anatomy/Digestive system/Gastrointestinal tract/Stomach" ], [ "plos", "/Medicine and health sciences/Clinical medicine/Signs and symptoms/Inflammation" ], [ "plos", "/Medicine and health sciences/Clinical medicine/Signs and symptoms/Ulcers" ], [ "plos", "/Medicine and health sciences/Clinical medicine/Signs and symptoms/Ulcers/Peptic ulcers/Gastric ulcers" ], [ "plos", "/Medicine and health sciences/Immunology/Immune response/Inflammation" ], [ "plos", "/Medicine and health sciences/Pathology and laboratory medicine/Toxicology/Toxicity" ], [ "plos", "/Physical sciences/Chemistry/Chemical compounds/Organic compounds/Alcohols/Ethanol" ], [ "plos", "/Physical sciences/Chemistry/Organic chemistry/Organic compounds/Alcohols/Ethanol" ] ], "openalex": "W7213409266", "pdf_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0355381&type=printable", "pmcid": null, "pmid": null, "published": "2026-09-16", "publisher": "Public Library of Science", "ris": "https://research.draconitic.com/paper/8wbxk5hskrkdj.ris", "sources": [ { "first_seen": "2026-10-30T12:17:49Z", "native_id": "10.1371/journal.pone.0355381", "source": "plos", "url": "https://doi.org/10.1371/journal.pone.0355381" } ], "subjects": [ { "field": "biology", "origin": "plos:immunology", "subfield": "immunology" }, { "field": "medicine", "origin": "plos:toxicology", "subfield": "pharmacology-toxicology" }, { "field": "medicine", "origin": "plos:anatomy", "subfield": "physiology" } ], "title": "Tragopogon coelesyriacus Boiss. attenuates ethanol-induced gastric ulcer in vivo: modulation of oxidative stress, inflammation, and apoptosis", "title_text": "Tragopogon coelesyriacus Boiss. attenuates ethanol-induced gastric ulcer in vivo: modulation of oxidative stress, inflammation, and apoptosis", "type": "peer-reviewed", "updated_at": "2026-10-30T12:17:49Z", "url": "https://research.draconitic.com/paper/8wbxk5hskrkdj", "venue": "PLOS One", "versions": [] }