{
  "abstract": "Objective Pancreatic cancer (PC) is one of the most refractory malignancies with a poor prognosis. However, improvements in the PC prognosis over time have not yet been thoroughly evaluated.We herein present a retrospective analysis of a prospectively maintained hospital-based cancer registry over 14 years. Methods The patients were prospectively enrolled in a Japanese government study. The period from 2007 to 2020 was divided into two seven-year periods to assess a prognostic improvement. The most recent censorship date is December 2024. Prognostic trends were compared across three treatment modalities: surgery, chemotherapy, and best supportive care (BSC). Results A total of 26,379 patients with all cancer types were prospectively enrolled over 14 years. Among these, 711 (2.7%) were enrolled for PC. Dichotomizing the period into the first and second halves, both the surgery group (18.7 months vs. 48.5 months, HR 0.45, P <0.001) and the chemotherapy group (9.1 months vs. 12.0 months, HR 0.58, P <0.001) had significantly better outcomes in the second half than in the first half. In the surgery group, the tumors were significantly smaller (P = 0.001) and detected earlier in the second half than in the first half (P = 0.007). In the chemotherapy group, the first-line treatment shifted from gemcitabine to gemcitabine plus nab-paclitaxel (GnP) in the second half (P <0.001). No significant improvement in the prognosis was observed in the BSC group (P = 0.597). Conclusions Prospective real-world data from 2007 to 2020 revealed that improvements in the early detection and adoption of GnP were temporally associated with an improved survival in patients with PC.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 19,
  "authors": [
    {
      "name": "Akinori Abe"
    },
    {
      "name": "Hiroshi Ohyama"
    },
    {
      "name": "Yoshiki Asahina"
    },
    {
      "name": "Kowa Nagasaka"
    },
    {
      "name": "Shodai Tohyama"
    },
    {
      "name": "Hiroyuki Amano"
    },
    {
      "name": "Shinya Takaoka"
    },
    {
      "name": "Yushi Imai"
    },
    {
      "name": "Sumio Hirose"
    },
    {
      "name": "Yukiko Asakawa"
    },
    {
      "name": "Ritsuko Yokouchi"
    },
    {
      "name": "Naho Sato"
    },
    {
      "name": "Yuko Hasegawa"
    },
    {
      "name": "Atsushi Takano"
    },
    {
      "name": "Yuji Iimuro"
    },
    {
      "name": "Yuichiro Kojima"
    },
    {
      "name": "Hitoshi Mochizuki"
    },
    {
      "name": "Jun Kato"
    },
    {
      "name": "Masao Omata"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8wbzajmezdcs3.bib",
  "cited_by": 0,
  "doi": "10.2169/internalmedicine.6719-25",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/internalmedicine/65/21/65_6719-25/_article",
  "id": "8wbzajmezdcs3",
  "issns": [
    "1349-7235",
    "0918-2918"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/internalmedicine/65/21/65_6719-25/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/general"
    ],
    [
      "openalex",
      "2730|Pancreatic and Hepatic Oncology Research"
    ]
  ],
  "openalex": "W7143282544",
  "pdf_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_6719-25/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/8wbzajmezdcs3.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T12:20:57Z",
      "native_id": "10.2169/internalmedicine.6719-25",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/internalmedicine/65/21/65_6719-25/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Pancreatic and Hepatic Oncology Research",
      "subfield": "oncology"
    }
  ],
  "title": "A Real-world Study on the Prognosis of Patients with Pancreatic Cancer: A Prospective Stationary Survey from 2007-2020",
  "title_text": "A Real-world Study on the Prognosis of Patients with Pancreatic Cancer: A Prospective Stationary Survey from 2007-2020",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:20:33Z",
  "url": "https://research.draconitic.com/paper/8wbzajmezdcs3",
  "venue": "Internal Medicine",
  "versions": []
}