{
  "abstract": "Background Functional mitral regurgitation is one of the severe complications of non-ischemic dilated cardiomyopathy (DCM). Non-contrast native T 1 mapping has emerged as a non-invasive method to evaluate myocardial fibrosis . We sought to evaluate the potential relationship between papillary muscle T 1 time and mitral regurgitation in DCM patients. Methods Forty DCM patients (55 ± 13 years) and 20 healthy adult control subjects (54 ± 13 years) were studied. Native T 1 mapping was performed using a slice interleaved T 1 mapping sequence (STONE) which enables acquisition of 5 slices in the short-axis plane within a 90 s free-breathing scan. We measured papillary muscle diameter, length and shortening. DCM patients were allocated into 2 groups based on the presence or absence of functional mitral regurgitation. Results Papillary muscle T 1 time was significantly elevated in DCM patients with mitral regurgitation ( n = 22) in comparison to those without mitral regurgitation ( n = 18) (anterior papillary muscle: 1127 ± 36 msec vs 1063 ± 16 msec, p < 0.05; posterior papillary muscle: 1124 ± 30 msec vs 1062 ± 19 msec, p < 0.05), but LV T 1 time was similar (1129 ± 38 msec vs 1134 ± 58 msec, p = 0.93). Multivariate linear regression analysis showed that papillary muscle native T 1 time (β = 0.10, 95 % CI: 0.05–0.17, p < 0.05) is significantly correlated with mitral regurgitant fraction . Elevated papillary muscle T 1 time was associated with larger diameter, longer length and decreased papillary muscle shortening (all p values <0.05). Conclusions In DCM, papillary muscle native T 1 time is significantly elevated and related to mitral regurgitant fraction.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "name": "Shingo Kato"
    },
    {
      "name": "Shiro Nakamori"
    },
    {
      "name": "Sébastien Roujol"
    },
    {
      "name": "Francesca Delling"
    },
    {
      "name": "Shadi Akhtari"
    },
    {
      "name": "Jihye Jang"
    },
    {
      "name": "Tamer Basha"
    },
    {
      "name": "Sophie Berg"
    },
    {
      "name": "Kraig Kissinger"
    },
    {
      "name": "Beth Goddu"
    },
    {
      "name": "Warren Manning"
    },
    {
      "name": "Reza Nezafat"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8x13999jbgar5.bib",
  "cited_by": 14,
  "doi": "10.1186/s12968-016-0301-y",
  "fulltext_url": null,
  "id": "8x13999jbgar5",
  "issns": [
    "1097-6647",
    "1532-429X"
  ],
  "landing_url": "https://hal.science/hal-05796056v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.ib"
    ],
    [
      "openalex",
      "2705|Cardiac Valve Diseases and Treatments"
    ]
  ],
  "openalex": "W2553106500",
  "pdf_url": "https://jcmr-online.biomedcentral.com/track/pdf/10.1186/s12968-016-0301-y",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-12",
  "publisher": "BioMed Central : Elsevier",
  "ris": "https://research.draconitic.com/paper/8x13999jbgar5.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:55Z",
      "native_id": "hal-05796056",
      "source": "hal",
      "url": "https://hal.science/hal-05796056v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sdv.ib",
      "subfield": "systems-synthetic"
    }
  ],
  "title": "Relationship between native papillary muscle T1 time and severity of functional mitral regurgitation in patients with non-ischemic dilated cardiomyopathy",
  "title_text": "Relationship between native papillary muscle T1 time and severity of functional mitral regurgitation in patients with non-ischemic dilated cardiomyopathy",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:55Z",
  "url": "https://research.draconitic.com/paper/8x13999jbgar5",
  "venue": "Journal of Cardiovascular Magnetic Resonance",
  "versions": []
}