{
  "abstract": "Peritoneal mesothelioma is a rare tumor, with few reports describing microsatellite instability. Lynch syndrome is a hereditary cancer predisposition syndrome commonly associated with colorectal and endometrial cancers. However, reports of peritoneal mesothelioma are rare. We herein describe a 48-year-old patient diagnosed with peritoneal mesothelioma and Lynch syndrome through comprehensive genomic profiling at the time of recurrence. Subsequent treatment with nivolumab plus ipilimumab resulted in a remarkable response. This case highlights the utility of genomic profiling during cancer treatment in uncovering unexpected hereditary cancer syndromes and thus guiding the selection of effective therapies.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "name": "Yuko Ueda"
    },
    {
      "name": "Rei Fukuda"
    },
    {
      "name": "Takayuki Ando"
    },
    {
      "name": "Yurika Nakayama"
    },
    {
      "name": "Iori Motoo"
    },
    {
      "name": "Shinya Kajiura"
    },
    {
      "name": "Isaya Hashimoto"
    },
    {
      "name": "Toru Watanabe"
    },
    {
      "name": "Takashi Minamisaka"
    },
    {
      "name": "Kenichi Hirabayashi"
    },
    {
      "name": "Yukihide Kanemitsu"
    },
    {
      "name": "Tsutomu Fujii"
    },
    {
      "name": "Ichiro Yasuda"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8x249hh16q8vd.bib",
  "cited_by": 0,
  "doi": "10.2169/internalmedicine.7052-25",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7052-25/_article",
  "id": "8x249hh16q8vd",
  "issns": [
    "1349-7235",
    "0918-2918"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7052-25/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/general"
    ],
    [
      "openalex",
      "2746|Intraperitoneal and Appendiceal Malignancies"
    ]
  ],
  "openalex": "W7170947471",
  "pdf_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7052-25/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-25",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/8x249hh16q8vd.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:31Z",
      "native_id": "10.2169/internalmedicine.7052-25",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7052-25/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Intraperitoneal and Appendiceal Malignancies",
      "subfield": "surgery"
    }
  ],
  "title": "Peritoneal mesothelioma showing a remarkable response to nivolumab plus ipilimumab in a patient with Lynch syndrome: A case report and literature review",
  "title_text": "Peritoneal mesothelioma showing a remarkable response to nivolumab plus ipilimumab in a patient with Lynch syndrome: A case report and literature review",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:31Z",
  "url": "https://research.draconitic.com/paper/8x249hh16q8vd",
  "venue": "Internal Medicine",
  "versions": []
}