{
  "abstract": "Membrane proteins (MPs) are vital drug targets, yet existing resources are fragmented across structural, pharmacological, and disease domains, limiting integrated exploration. To address this, we developed the Membrane Protein-Drug-Disease (MPDD) Database (https://chemyang.ccnu.edu.cn/ccb/server/MPDD/), a curated platform explicitly linking MPs, drugs, and diseases. MPDD currently includes 1523 MP targets, 589 diseases, and 18,489 drugs. It offers multi-dimensional query tools, interactive classification trees, drug property analysis, BLAST search, and co-target network visualization. By unifying the MP-drug-disease triad, MPDD aims to accelerate mechanistic studies, druggability evaluation, and targeted therapy discovery.",
  "abstract_shown": true,
  "affiliations": [
    "Central China Normal University , , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Zongwei Lu"
    },
    {
      "affs": [
        0
      ],
      "name": "Junhao Ma"
    },
    {
      "affs": [
        0
      ],
      "name": "Jinpeng Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Fan Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaolei Zhu",
      "orcid": "0000-0002-5672-5209"
    },
    {
      "affs": [
        0
      ],
      "name": "Guangfu Yang",
      "orcid": "0000-0003-4384-2593"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8x6rdej88vxkz.bib",
  "cited_by": 0,
  "doi": "10.1021/acsomega.6c07804",
  "fulltext_url": "https://europepmc.org/articles/PMC13688505",
  "id": "8x6rdej88vxkz",
  "issns": [
    "2470-1343"
  ],
  "landing_url": "https://pubs.acs.org/acsodf/article/11/41/63734/5448160/MPDD-A-Curated-Database-Bridging-Membrane-Protein",
  "language": "eng",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1703|Computational Drug Discovery Methods"
    ]
  ],
  "openalex": "W7221104551",
  "pdf_url": "https://pubs.acs.org/doi/pdf/10.1021/acsomega.6c07804",
  "pmcid": "PMC13688505",
  "pmid": "42923984",
  "published": "2026-10-09",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/8x6rdej88vxkz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:39Z",
      "native_id": "10.1021/acsomega.6c07804",
      "source": "crossref",
      "url": "https://pubs.acs.org/acsodf/article/11/41/63734/5448160/MPDD-A-Curated-Database-Bridging-Membrane-Protein"
    },
    {
      "first_seen": "2026-10-30T12:20:33Z",
      "native_id": "MED:42923984",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42923984"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "issn:2470-1343",
      "subfield": "general"
    }
  ],
  "title": "MPDD: A Curated Database Bridging Membrane Protein-Drug-Disease Landscapes",
  "title_text": "MPDD: A Curated Database Bridging Membrane Protein-Drug-Disease Landscapes",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:33Z",
  "url": "https://research.draconitic.com/paper/8x6rdej88vxkz",
  "venue": "ACS Omega",
  "versions": []
}