{
  "abstract": "The present retrospective study evaluated the supplementary value of gross tumor volume of the primary nasopharyngeal tumor (GTVnx) for overall survival (OS) risk stratification in patients with T3-4 nasopharyngeal carcinoma (NPC). A total of 118 patients with T3-4 NPC who received definitive intensity-modulated radiotherapy at Guilin People's Hospital (Guilin, China) between March 2020 and June 2025 were included. GTVnx was obtained from the radiotherapy planning system. A time-dependent receiver operating characteristic (ROC) curve was used to determine the exploratory cut-off for predicting 3-year OS. Survival differences were assessed using the Kaplan-Meier method and log-rank test, and Cox proportional hazards models were used to evaluate the association between GTVnx and OS. Clinical and extended models were compared using the concordance index (C-index), Akaike information criterion (AIC) and time-dependent area under the curve (AUC), and sensitivity analyses were performed to assess robustness. The median follow-up time was 34.1 months and 18 deaths occurred (15.3%). The 36-month time-dependent ROC analysis identified 78 cm3 as the exploratory cut-off for GTVnx, with an AUC of 0.709. Patients with high GTVnx had poorer OS than those with low GTVnx (log-rank P<0.001). In a multivariable Cox analysis, high GTVnx remained associated with poorer OS after adjustment for T stage and pretreatment Epstein-Barr virus DNA (EBV DNA; hazard ratio, 4.375; 95% confidence interval, 1.474–12.986; P=0.008). Adding GTVnx to the clinical model improved the C-index from 0.759 to 0.817, reduced the AIC from 135.151 to 133.085 and increased the 36-month AUC from 0.748 to 0.787. Sensitivity analyses supported the consistency of the main findings. GTVnx may provide supplementary prognostic information beyond T stage and pretreatment EBV DNA in patients with T3-4 NPC. However, the identified cut-off value and incremental prognostic value require validation in independent cohorts.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Oncology and Radiotherapy, Guilin People's Hospital, Guilin, Guangxi 541002, P.R. China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Hui Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yusong Lu"
    },
    {
      "affs": [
        0
      ],
      "name": "Yingjie Ouyang"
    },
    {
      "affs": [
        0
      ],
      "name": "Min Pan"
    },
    {
      "affs": [
        0
      ],
      "name": "Xinyu Tang"
    },
    {
      "affs": [
        0
      ],
      "name": "Hongrui He"
    },
    {
      "affs": [
        0
      ],
      "name": "Tingfeng Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Qi Gong"
    },
    {
      "affs": [
        0
      ],
      "name": "Chunqiao Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Qiuqiu Chen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8x8b0r9c9dvdw.bib",
  "cited_by": 0,
  "doi": "10.3892/ol.2026.15904",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13698795/",
  "id": "8x8b0r9c9dvdw",
  "issns": [
    "1792-1074",
    "1792-1082"
  ],
  "landing_url": "https://doi.org/10.3892/ol.2026.15904",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Articles"
    ],
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      "openalex",
      "2733|Head and Neck Cancer Studies"
    ]
  ],
  "openalex": "W7221716574",
  "pdf_url": "https://europepmc.org/articles/PMC13698795?pdf=render",
  "pmcid": "PMC13698795",
  "pmid": "42936491",
  "published": "2026-10-13",
  "publisher": "Spandidos Publications",
  "ris": "https://research.draconitic.com/paper/8x8b0r9c9dvdw.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:30Z",
      "native_id": "PMC13698795",
      "source": "pmc",
      "url": "https://doi.org/10.3892/ol.2026.15904"
    },
    {
      "first_seen": "2026-10-30T12:22:12Z",
      "native_id": "MED:42936491",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42936491"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2733|Head and Neck Cancer Studies",
      "subfield": "general"
    }
  ],
  "title": "Supplementary value of primary tumor volume for prognostic stratification in patients with T3-4 nasopharyngeal carcinoma: A retrospective cohort study",
  "title_text": "Supplementary value of primary tumor volume for prognostic stratification in patients with T3-4 nasopharyngeal carcinoma: A retrospective cohort study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:35:29Z",
  "url": "https://research.draconitic.com/paper/8x8b0r9c9dvdw",
  "venue": "Oncology Letters",
  "versions": []
}