{
  "abstract": "Background: The LAST-long randomized trial tested a multidimensional, stroke coordinator-led, community-based intervention and found no overall functional benefit. Because most participants had mild stroke symptoms, whether older or frailer subgroups benefited was examined.\n\nMethods: In this single-blinded RCT at 4 Norwegian hospitals (2019–2022), 301 participants were randomized 1:1 to monthly stroke-coordinator meetings for 18 months (structured risk assessment and individualized goals) or to standard care. Primary outcome: modified Rankin Scale (mRS) at 18 months. Secondary outcomes: mortality, cognition, ADLs, physical function, fatigue, and quality of life. Older age: ≥ 80 years; frailty: Frailty Index ≥ 0.2. Linear and logistic regression tested age- and frailty-intervention interactions.\n\nResults: mRS data were available for 268 participants (136 intervention, 132 control). Mean age 71.1 (SD 12.4); 66 (24.6%) ≥ 80; 89 (33.2%) frail. Age modified the intervention effect on mRS: among participants ≥ 80, favourable outcome was less likely with intervention vs control (23.4% vs 57.0%, p = 0.004). For secondary outcomes, the intervention improved Trail Making Test B in younger participants (−32.2 s, 95% CI −58.0 to −6.4, p = 0.015) with a significant age–intervention interaction (p = 0.019). No frailty–intervention interaction was found.\n\nConclusions: Age – but not frailty – modified response to the intervention, indicating differential effects in older participants.\n\nClinical Trials.gov identifier: NCT03859063",
  "abstract_shown": true,
  "affiliations": [
    "Medical department, Bærum Hospital, Vestre Viken Hospital Trust, Bærum, Norway",
    "Department of Neurology, Division of Medicine, Akershus University Hospital, Akershus, Norway",
    "Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Science, NTNU-Norwegian University of Science and Technology, Trondheim, Norway; Clinic of Rehabilitation, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway",
    "Regional Centre for Child and Youth Mental Health and Child Welfare, Department of Mental Health, Faculty of Medicine and Health Science, NTNU-Norwegian University of Science and Technology, Trondheim, Norway",
    "Department of Medicine, Ålesund Hospital, Helse Møre and Romsdal Hospital Trust, Ålesund, Norway.",
    "Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Science, NTNU-Norwegian University of Science and Technology, Trondheim, Norway; Department of Geriatrics, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway",
    "Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Science, NTNU-Norwegian University of Science and Technology, Trondheim, Norway; Clinic of Internal Medicine, Department of Stroke, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
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        0
      ],
      "name": "Håkon Ihle-Hansen"
    },
    {
      "affs": [
        1
      ],
      "name": "Bente Thommessen"
    },
    {
      "affs": [
        2
      ],
      "name": "Sara Rise Langlo"
    },
    {
      "affs": [
        1
      ],
      "name": "Elin Bergh"
    },
    {
      "affs": [
        2
      ],
      "name": "Anne Hokstad"
    },
    {
      "affs": [
        3
      ],
      "name": "Stian Lydersen"
    },
    {
      "affs": [
        4
      ],
      "name": "Yngve Seljeseth"
    },
    {
      "affs": [
        5
      ],
      "name": "Ingvild Saltvedt"
    },
    {
      "affs": [
        6
      ],
      "name": "Torunn Askim"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8xwkwcf1wgcs7.bib",
  "cited_by": 0,
  "doi": "10.2340/jrm.v58.46250",
  "fulltext_url": "https://medicaljournalssweden.se/jrm/article/view/46250",
  "id": "8xwkwcf1wgcs7",
  "issns": [
    "1651-2081",
    "1650-1977"
  ],
  "landing_url": "https://doi.org/10.2340/jrm.v58.46250",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Report"
    ],
    [
      "lcc",
      "RM1-950"
    ],
    [
      "openalex",
      "2742|Stroke Rehabilitation and Recovery"
    ]
  ],
  "openalex": "W7223706288",
  "pdf_url": "https://medicaljournalssweden.se/jrm/article/download/46250/55954",
  "pmcid": "PMC13717427",
  "pmid": "42929098",
  "published": "2026-10-26",
  "publisher": "Medical Journals Sweden",
  "ris": "https://research.draconitic.com/paper/8xwkwcf1wgcs7.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:47:31Z",
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      "url": "https://doi.org/10.2340/jrm.v58.46250"
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      "native_id": "PMC13717427",
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  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RM1-950",
      "subfield": "pharmacology-toxicology"
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  ],
  "title": "Impact of age and frailty on the effect of a multimodal individualized long-term intervention after stroke: the last-long trial",
  "title_text": "Impact of age and frailty on the effect of a multimodal individualized long-term intervention after stroke: the last-long trial",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:21:45Z",
  "url": "https://research.draconitic.com/paper/8xwkwcf1wgcs7",
  "venue": "Journal of Rehabilitation Medicine",
  "versions": []
}