{
  "abstract": "2 ABSTRACT: Reductive deoxygenation of benzylic alcohols is a valuable transformation that yields alkylated aromatic compounds. Even though hydroxyl group in these substrates is considered as activated, general mild methods for their reduction remain elusive. While many existing protocols require acidic reagents or additives detrimental for functional groups, milder alternatives are efficient only with 1° benzylic alcohols and diarylmethanols. Here we report that low-valent titanium alkoxides promote deoxygenation of 1°, 2° and 3° benzylic alcohols under basic conditions compatible with acetal, alkene, ester, amide, nitrile, aryl halides and benzyloxy groups. The low-valent titanium reagents were generated in situ by the reduction of Ti(OiPr)4 either with a dihydrobenzimidazol derivative under irradiation with blue light or with pieces of sodium metal. Mechanistic studies revealed that the deoxygenation step is promoted by Ti(III) alkoxides, while OH-groups of the substrate serve as a source of H-atoms.",
  "abstract_shown": true,
  "affiliations": [
    "Republican Scientific Center of Human Issues, Belarusian State University, Kurčatava 7, Minsk, Belarus, 220064",
    "National Anti-Doping Laboratory",
    "Scientific Testing Center Campilab Ltd., Centraĺnaja 30A, Dynaraŭka, Belarus, 222202"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Dziyana Atroshchanka"
    },
    {
      "affs": [
        0
      ],
      "name": "Yahor Rusakovich"
    },
    {
      "affs": [
        0
      ],
      "name": "Antanina Shtytsko"
    },
    {
      "affs": [
        0
      ],
      "name": "Mark Senkevich"
    },
    {
      "affs": [
        0
      ],
      "name": "Gleb Kakouka"
    },
    {
      "affs": [
        1
      ],
      "name": "Vitaly Syakhovich"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Alaksiej Hurski",
      "orcid": "0000-0002-8599-2621"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8xxg71f2apqq1.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15009976/v1",
  "fulltext_url": null,
  "id": "8xxg71f2apqq1",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009976/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Organometallic Complex Synthesis and Catalysis"
    ]
  ],
  "openalex": "W7220694149",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15009976/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-06",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/8xxg71f2apqq1.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:22Z",
      "native_id": "10.26434/chemrxiv.15009976",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009976/v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Organometallic Complex Synthesis and Catalysis",
      "subfield": "organic"
    }
  ],
  "title": "Reductive Deoxygenation of Benzylic Alcohols by Low-Valent Titanium Alkoxides",
  "title_text": "Reductive Deoxygenation of Benzylic Alcohols by Low-Valent Titanium Alkoxides",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:22Z",
  "url": "https://research.draconitic.com/paper/8xxg71f2apqq1",
  "venue": "ChemRxiv",
  "versions": []
}