{
  "abstract": "Background\n\nSpatiotemporal transcriptomics (STT) integrates spatially resolved gene expression with temporal information derived from staged samples, paired treatment specimens, or computational inference, providing a framework for reconstructing tissue-level dynamics. In the tumour microenvironment (TME), STT extends static molecular and cellular maps by revealing how cellular neighbourhoods and functional niches are reorganised during tumour evolution.Main text\n\nThis review examines how STT characterises TME remodelling during malignant transformation, invasion, metastasis, ageing, and treatment response. We discuss strategies for resolving temporal dynamics, including stage-stratified sampling, paired or serial specimens, pseudotime and trajectory inference, and complementary intravital imaging. We further consider how spatiotemporal analyses can connect changes in cellular states, spatial organisation, and intercellular interactions with clinically relevant tumour phenotypes.Conclusion\n\nBy linking the spatial organisation of the TME with stage- and treatment-associated molecular changes, STT may improve the prioritisation of candidate targets, treatment stratification, and the development of precision oncology strategies.",
  "abstract_shown": true,
  "affiliations": [
    "Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China.",
    "School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, China."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ying Kang"
    },
    {
      "affs": [
        0
      ],
      "name": "Qinjing Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Siqi Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiming Guo"
    },
    {
      "affs": [
        1
      ],
      "name": "Yue Ming"
    },
    {
      "affs": [
        1
      ],
      "name": "Weixing Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Min Wang",
      "orcid": "0009-0005-2798-8607"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhijie Huang",
      "orcid": "0000-0002-7312-4982"
    },
    {
      "affs": [
        0
      ],
      "name": "Yisheng Huang",
      "orcid": "0000-0002-3654-6561"
    },
    {
      "affs": [
        0
      ],
      "name": "Bo Jia",
      "orcid": "0000-0002-7178-424X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8xxs455t911yk.bib",
  "cited_by": 0,
  "doi": "10.1002/ctm2.70858",
  "fulltext_url": "https://europepmc.org/articles/PMC13655377",
  "id": "8xxs455t911yk",
  "issns": [
    "2001-1326"
  ],
  "landing_url": "https://europepmc.org/article/MED/42860711",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "R5-920"
    ],
    [
      "openalex",
      "1312|Single-cell and spatial transcriptomics"
    ]
  ],
  "openalex": "W7221552096",
  "pdf_url": "https://europepmc.org/articles/PMC13655377?pdf=render",
  "pmcid": "PMC13655377",
  "pmid": "42860711",
  "published": "2026-10-01",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/8xxs455t911yk.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:16Z",
      "native_id": "MED:42860711",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42860711"
    },
    {
      "first_seen": "2026-10-30T13:47:26Z",
      "native_id": "0dec246a252146f199e68125d5147f32",
      "source": "doaj",
      "url": "https://doi.org/10.1002/ctm2.70858"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Single-cell and spatial transcriptomics",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Spatiotemporal transcriptomics for tumour microenvironment remodelling in cancer progression and therapy.",
  "title_text": "Spatiotemporal transcriptomics for tumour microenvironment remodelling in cancer progression and therapy.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T14:21:09Z",
  "url": "https://research.draconitic.com/paper/8xxs455t911yk",
  "venue": "Clinical and translational medicine",
  "versions": []
}