{
  "abstract": "Despite advancements in comprehensive treatment strategies, recurrent oral cavity cancer remains a major clinical challenge. Although salvage surgery has been the cornerstone for managing locoregional recurrent oral cavity squamous cell carcinoma (OCSCC), the role of salvage radiotherapy in radiation-naïve patients is not well established. This retrospective single-centre study included 56 radiation-naïve patients with recurrent OCSCC who were treated between May 2007 and September 2023. All patients underwent either definitive radiotherapy without surgery (RT) or adjuvant radiotherapy following surgery (S + RT). Univariate and multivariate Cox proportional hazards models were used to identify the prognostic factors. The 2-year overall survival (OS) and progression-free survival (PFS) rates for the entire cohort were 58.9% and 37.7%, respectively, with median OS and PFS of 48.7 and 8.3 months. Patients who underwent S + RT (n = 40) demonstrated favourable trends in OS (62.8% vs. 48.9%, p = 0.704) and PFS (43.5% vs. 23.4%, p = 0.104) compared with those treated with RT alone (n = 16), although the differences did not reach statistical significance. Multivariate analysis identified poor performance status as an independent adverse prognostic factor for OS [hazard ratio (HR) = 3.638, p = 0.008] and PFS (HR = 2.780; p = 0.008). Early recurrence within 6 months also significantly predicted worse PFS (HR = 2.554, p = 0.013). Salvage radiotherapy with or without surgical intervention is a feasible treatment option for radiation-naïve patients with recurrent OCSCC. While no statistically significant differences were observed between treatment approaches, patient-related factors such as performance status and recurrence interval were significantly associated with outcomes and may be important for treatment selection.",
  "abstract_shown": true,
  "affiliations": [
    "The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.",
    "Department of Radiology, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.",
    "Department of Otolaryngology and Head and Neck Surgery, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Atsuto Katano"
    },
    {
      "affs": [
        1
      ],
      "name": "Akiko Oka"
    },
    {
      "affs": [
        1
      ],
      "name": "Masanari Minamitani"
    },
    {
      "affs": [
        2
      ],
      "name": "Yusuke Ito"
    },
    {
      "affs": [
        2
      ],
      "name": "Koji Yamamura"
    },
    {
      "affs": [
        2
      ],
      "name": "Kenya Kobayashi"
    },
    {
      "affs": [
        2
      ],
      "name": "Yuki Saito"
    },
    {
      "affs": [
        0
      ],
      "name": "Hideomi Yamashita"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8z5ybtet23nbr.bib",
  "cited_by": 0,
  "doi": "10.5603/rpor.113325",
  "fulltext_url": "https://europepmc.org/articles/PMC13743163",
  "id": "8z5ybtet23nbr",
  "issns": [
    "1507-1367",
    "2083-4640"
  ],
  "landing_url": "https://europepmc.org/article/MED/42997872",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2733|Head and Neck Cancer Studies"
    ]
  ],
  "openalex": "W7168912795",
  "pdf_url": "https://europepmc.org/articles/PMC13743163?pdf=render",
  "pmcid": "PMC13743163",
  "pmid": "42997872",
  "published": "2026-11-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/8z5ybtet23nbr.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T15:20:34Z",
      "native_id": "MED:42997872",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42997872"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2733|Head and Neck Cancer Studies",
      "subfield": "general"
    }
  ],
  "title": "Salvage radiotherapy with or without surgical intervention for recurrent oral cavity squamous cell carcinomas in radiation-naïve patients: a retrospective single-centre study.",
  "title_text": "Salvage radiotherapy with or without surgical intervention for recurrent oral cavity squamous cell carcinomas in radiation-naïve patients: a retrospective single-centre study.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T15:20:34Z",
  "url": "https://research.draconitic.com/paper/8z5ybtet23nbr",
  "venue": "Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology",
  "versions": []
}