{
  "abstract": "Chronic cerebral hypoperfusion (CCH), a key contributor to vascular dementia (VaD), causes white matter injury and neuroinflammation. We evaluated the neuroprotective effects of 6-gingerol-rich Zingiberis Rhizoma ethanol extract (ZRex) in a mouse bilateral common carotid artery stenosis (BCAS) model. BCAS-operated C57BL/6 mice received oral ZRex (30, 100, or 300 mg/kg, three times weekly). Spatial working memory, recognition memory, glial activation, oligodendrocyte and myelin markers, RNA sequencing (RNA-seq), and 6-gingerol molecular docking were evaluated. ZRex partially restored recognition memory in the novel object recognition test without altering Y-maze spatial working memory. BCAS significantly increased platelet-derived growth factor receptor alpha-positive cell counts, which ZRex restored toward sham levels. ZRex also markedly attenuated cluster of differentiation 68 immunoreactivity. RNA-seq identified 479 BCAS-responsive candidate genes (fold-change-filtered) and demonstrated that ZRex selectively restored downregulated transcripts. Molecular docking revealed the strongest predicted binding of 6-gingerol to Mup19 (Vina score: −9.4 kcal/mol), followed by Serpina3, Saa2, Mup1, and F10. Overall, ZRex attenuated BCAS-induced recognition memory deficits and neuroinflammation by modulating metabolic and inflammatory pathways, potentially mediated by direct 6-gingerol interactions with candidate targets. These findings support ZRex as a promising botanical candidate for VaD.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Korean Medicine, College of Korean Medicine, Dong-Eui University, Busan 47227, Republic of Korea",
    "Center for Advanced Medical Computing and Analysis, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA",
    "School of Public Health, Far East University, Eumseong 27601, Republic of Korea",
    "Department of Korean Medicine, School of Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Taeyoung Huh"
    },
    {
      "affs": [
        1
      ],
      "name": "Chiyeon Lim"
    },
    {
      "affs": [
        2
      ],
      "name": "Sehyun Lim"
    },
    {
      "affs": [
        0
      ],
      "name": "Kyung-Min Kim"
    },
    {
      "affs": [
        3
      ],
      "name": "Suin Cho",
      "orcid": "0000-0001-8507-1382"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8z7efvqqma81k.bib",
  "cited_by": 0,
  "doi": "10.3390/molecules31203634",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13707571/?tool=EBI",
  "id": "8z7efvqqma81k",
  "issns": [
    "1420-3049"
  ],
  "landing_url": "https://www.mdpi.com/1420-3049/31/20/3634",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2808|Neurological Disease Mechanisms and Treatments"
    ]
  ],
  "openalex": "W7221518919",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13707571/pdf/?tool=EBI",
  "pmcid": "PMC13707571",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/8z7efvqqma81k.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:42Z",
      "native_id": "10.3390/molecules31203634",
      "source": "crossref",
      "url": "https://www.mdpi.com/1420-3049/31/20/3634"
    },
    {
      "first_seen": "2026-10-30T12:21:47Z",
      "native_id": "PMC:PMC13707571",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13707571"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2808|Neurological Disease Mechanisms and Treatments",
      "subfield": "neurology"
    }
  ],
  "title": "Zingiberis Rhizoma Ethanol Extract Attenuates Recognition Memory Deficits and Neuroinflammation in a Mouse Model of Bilateral Common Carotid Artery Stenosis",
  "title_text": "Zingiberis Rhizoma Ethanol Extract Attenuates Recognition Memory Deficits and Neuroinflammation in a Mouse Model of Bilateral Common Carotid Artery Stenosis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:47Z",
  "url": "https://research.draconitic.com/paper/8z7efvqqma81k",
  "venue": "Molecules",
  "versions": []
}