{
  "abstract": "Although functional neuroimaging studies using caloric and galvanic vestibular stimulation have identified a distributed cortical network involved in human vestibular processing, including the posterior insula, parietal operculum, temporo-parietal junction, cingulate and frontal areas, the causal contribution of specific brain regions to vestibular self-motion perception remains poorly understood. Invasive electrical brain stimulation (EBS) during stereoelectroencephalography (SEEG) offers a unique opportunity to causally map the cortical networks underlying vestibular self-motion perception in humans.\n\nHere, we retrospectively analyzed EBS-induced vestibular percepts in 354 patients with drugresistant epilepsy undergoing SEEG. A total of 19,708 stimulations (11,004 at 50 Hz and 8,704 at 1 Hz) yielded 3,015 clinical responses. Vestibular self-motion illusions were defined as sensations of vertigo, dizziness, whole-body rotation, or translation occurring without corresponding physical movement. Stimulation sites were assigned to the seven large-scale functional networks of the Schaefer-Yeo atlas to characterize the network organization of vestibular self-motion perception.\n\nVestibular self-motion sensations were elicited in 46 patients (21 females; mean age ± SD: 25 ± 11 years) during 86 EBS delivered outside epileptogenic and lesional regions. Percepts ranged from nonspecific vertigo and dizziness (54.7%) to more explicit rotational (30.2%) and translational (15.1%) self-motion illusions. Vestibular responses were most commonly evoked by stimulation of the insula, medial temporal regions, cingulate cortex, inferior frontal gyrus, and premotor cortices. Network-level mapping using the Schaefer-Yeo atlas revealed a non-uniform distribution of vestibular sites across large-scale functional networks, with the highest representation within the salience/ventral attention, visual, and dorsal attention networks.\n\nTogether, these findings provide causal evidence that vestibular self-motion perception emerges from activity within a distributed cortical network involved in attentional control and multisensory processing. Beyond advancing our understanding of human vestibular processing, these findings may have clinical relevance for disorders involving altered self-motion perception, including vestibular epilepsy and functional neurological disorders.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "name": "Zoé Dary"
    },
    {
      "name": "Stanislas Lagarde"
    },
    {
      "name": "Samuel Medina Villalon"
    },
    {
      "name": "Hugo Dary"
    },
    {
      "name": "Jacques Leonard"
    },
    {
      "name": "Fabrice Bartolomei"
    },
    {
      "name": "Christophe Lopez"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8zhhgymdythba.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.19.752147",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.19.752147v1.full",
  "id": "8zhhgymdythba",
  "issns": [],
  "landing_url": "https://hal.science/hal-05764213v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "neuroscience"
    ],
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.neu"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://hal.science/hal-05764213/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-19",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/8zhhgymdythba.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:41Z",
      "native_id": "hal-05764213",
      "source": "hal",
      "url": "https://hal.science/hal-05764213v1"
    },
    {
      "first_seen": "2026-10-30T12:24:29Z",
      "native_id": "10.64898/2026.09.19.752147",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.19.752147v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:neuroscience",
      "subfield": "neuroscience"
    }
  ],
  "title": "Causal mapping of self-motion networks in the human brain",
  "title_text": "Causal mapping of self-motion networks in the human brain",
  "type": "preprint",
  "updated_at": "2026-10-30T12:24:29Z",
  "url": "https://research.draconitic.com/paper/8zhhgymdythba",
  "venue": "HAL",
  "versions": []
}