{
  "abstract": "Therapeutic needs to modulate brain circuits highlight graphene-based materials (GBMs) as an emerging tool to engineer specific interventions to treat neuro-diseases. In this context, graphene oxide (GO) nanosheets offer new drug delivery strategies to reach neural cells and signaling networks selectively. To complex and transport neuropeptide Y (NPY), GO was engineered as GO:NPY, and its activity was investigated in regulating excitatory neurotransmission in NPY-positive synaptic pathways, when delivered to the amygdala, a structure mediating fear memory responses. First, it was shown that in vitro GO:NPY specifically and selectively inhibited glutamate release and suppressed synaptic enhancement via NPY receptors. In a rat model of anxiety disorder, when injected into the amygdala, GO:NPY suppressed contextual fear memory responses via activation of NPY receptors in specific synaptic pathways. This easy-to-tune GBM-based nanoplatforms promise advances in co-delivery vectors preserving the synaptic specificity needed for treating specific pathological conditions.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "name": "Elisa Pati"
    },
    {
      "name": "Audrey Franceschi Biagioni"
    },
    {
      "name": "Raffaele Casani"
    },
    {
      "name": "Luis M Arellano"
    },
    {
      "name": "Tommaso Battisti"
    },
    {
      "name": "Gloria Garcia‐ortega"
    },
    {
      "name": "Neus Lozano"
    },
    {
      "name": "Alberto Bianco"
    },
    {
      "name": "Kostas Kostarelos"
    },
    {
      "name": "Laura Ballerini"
    },
    {
      "name": "Giada Cellot"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/90js4yqa6r3xd.bib",
  "cited_by": 0,
  "doi": "10.1002/advs.76608",
  "fulltext_url": null,
  "id": "90js4yqa6r3xd",
  "issns": [
    "2198-3844"
  ],
  "landing_url": "https://hal.science/hal-05769758v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "2204|Graphene and Nanomaterials Applications"
    ]
  ],
  "openalex": "W7171923169",
  "pdf_url": "https://hal.science/hal-05769758/document",
  "pmcid": null,
  "pmid": "42535973",
  "published": "2026-07-31",
  "publisher": "Wiley Open Access",
  "ris": "https://research.draconitic.com/paper/90js4yqa6r3xd.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:43Z",
      "native_id": "hal-05769758",
      "source": "hal",
      "url": "https://hal.science/hal-05769758v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    }
  ],
  "title": "Neuropeptide Y—Graphene Oxide Complexes Inhibit Amygdala NPY‐Receptor Expressing Glutamatergic Pathways and Selectively Remove Aversive Memory In Vivo",
  "title_text": "Neuropeptide Y—Graphene Oxide Complexes Inhibit Amygdala NPY‐Receptor Expressing Glutamatergic Pathways and Selectively Remove Aversive Memory In Vivo",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:43Z",
  "url": "https://research.draconitic.com/paper/90js4yqa6r3xd",
  "venue": "Advanced Science",
  "versions": []
}