{
  "abstract": "Patients presenting with hemophagocytic lymphohistiocytosis (HLH) are often critically ill, and rapid identification of both HLH and underlying triggers in secondary HLH is essential for successful treatment. We present a case of secondary HLH activated by disseminated histoplasmosis (DH) that mimicked autoimmune hepatitis (AIH) on liver histology and briefly led to an incorrect liver diagnosis. Once DH was identified, he was treated with antifungals in addition to HLH therapies and stabilized. He was subsequently found to have a heterozygous variant of uncertain significance in STAT1. Our case is the first in the literature to describe liver biopsies in a pediatric patient who has DH that had triggered HLH, and due to striking histology that mimicked AIH, important to report.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition University of Wisconsin‐Madison Madison Wisconsin USA",
    "Department of Pediatrics, Division of Critical Care University of Wisconsin‐Madison Madison Wisconsin USA",
    "Department of Pathology and Laboratory Medicine University of Wisconsin‐Madison Madison Wisconsin USA",
    "Department of Pediatrics, Division of Infectious Diseases University of Wisconsin‐Madison Madison Wisconsin USA",
    "Department of Pediatrics, Division of Allergy, Immunology, and Rheumatology University of Wisconsin‐Madison Madison Wisconsin USA",
    "Department of Pediatrics, Division of Hematology, Oncology, Transplant, and Cellular Therapy University of Wisconsin‐Madison Madison Wisconsin USA",
    "Department of Pediatrics, Division of Genetics and Metabolism University of Wisconsin‐Madison Madison Wisconsin USA"
  ],
  "article_type": "case study",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Thomas Ratchford",
      "orcid": "0009-0007-0129-2032"
    },
    {
      "affs": [
        1
      ],
      "name": "Talal Al Hendawi",
      "orcid": "0009-0002-9587-8272"
    },
    {
      "affs": [
        2
      ],
      "name": "Eumenia Castro"
    },
    {
      "affs": [
        1
      ],
      "name": "Pelin Cengiz"
    },
    {
      "affs": [
        3
      ],
      "name": "James Conway"
    },
    {
      "affs": [
        2
      ],
      "name": "Shelly Cook"
    },
    {
      "affs": [
        4
      ],
      "name": "Leanne Mansfield"
    },
    {
      "affs": [
        5
      ],
      "name": "Nicholas Pytel"
    },
    {
      "affs": [
        4
      ],
      "name": "Christine M. Seroogy"
    },
    {
      "affs": [
        6
      ],
      "name": "Katelyn Watkin"
    },
    {
      "affs": [
        4
      ],
      "name": "Jo Wilson",
      "orcid": "0000-0002-1729-0863"
    },
    {
      "affs": [
        0
      ],
      "name": "Jonathan Wong",
      "orcid": "0000-0002-0288-4300"
    },
    {
      "affs": [
        5
      ],
      "name": "Therese Woodring",
      "orcid": "0000-0002-4219-0944"
    },
    {
      "affs": [
        0
      ],
      "name": "Katryn N. Furuya",
      "orcid": "0000-0002-7575-4443"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/91094fy6s8p9q.bib",
  "cited_by": 0,
  "doi": "10.1002/jpr3.70296",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13729236/?tool=EBI",
  "id": "91094fy6s8p9q",
  "issns": [
    "2691-171X"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13729236",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Case Report"
    ],
    [
      "openalex",
      "2720|Autoimmune and Inflammatory Disorders Research"
    ]
  ],
  "openalex": "W7225168952",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13729236/pdf/?tool=EBI",
  "pmcid": "PMC13729236",
  "pmid": "42979361",
  "published": "2026-11-03",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/91094fy6s8p9q.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:20:46Z",
      "native_id": "PMC:PMC13729236",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13729236"
    },
    {
      "first_seen": "2026-11-07T12:22:02Z",
      "native_id": "PMC13729236",
      "source": "pmc",
      "url": "https://doi.org/10.1002/jpr3.70296"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2720|Autoimmune and Inflammatory Disorders Research",
      "subfield": "general"
    }
  ],
  "title": "Disseminated histoplasmosis mimicking autoimmune hepatitis as a trigger of secondary hemophagocytic lymphohistiocytosis in a pediatric patient",
  "title_text": "Disseminated histoplasmosis mimicking autoimmune hepatitis as a trigger of secondary hemophagocytic lymphohistiocytosis in a pediatric patient",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:22:02Z",
  "url": "https://research.draconitic.com/paper/91094fy6s8p9q",
  "venue": "JPGN reports",
  "versions": []
}