{
  "abstract": "Background and Clinical Significance: Refractory below-knee amputation (BKA) stump wounds can delay prosthetic rehabilitation. This report describes wound healing during multimodal care that included autologous platelet-rich plasma (PRP) activated with autologous thrombin serum (ATS); Case Presentation: A 33-year-old man with Charcot-Marie-Tooth disease and a persistent right BKA stump wound after surgical revisions underwent three PRP-ATS applications on 16 and 23 February and 8 March 2026. Collagen dressings were applied on 2 and 15 March, and compression was continued thereafter. The estimated wound volume decreased from 14.18 cm³ at baseline to 0.48 cm³ at week 3 (approximately 97%); advanced epithelialization was observed at week 4. Complete closure was documented on 16 April 2026, approximately eight weeks after treatment began. No treatment-related adverse events were reported. After closure, the patient was referred for prosthetic rehabilitation assessment; fitting and functional use were not documented; Conclusions: Healing was temporally associated with PRP-ATS as part of a multimodal treatment course. This single case supports the feasibility of the approach but cannot establish the independent efficacy of PRP-ATS.",
  "abstract_shown": true,
  "affiliations": [
    "Nursing Department, Johns Hopkins Aramco Healthcare, Dhahran 31311, Saudi Arabia.",
    "Surgery Department, Johns Hopkins Aramco Healthcare, Dhahran 31311, Saudi Arabia.",
    "Research Office, Johns Hopkins Aramco Healthcare, Dhahran 31311, Saudi Arabia.",
    "College of Medicine, Umm Al-Qura University, Makkah 21955, Saudi Arabia."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Khansa Shara",
      "orcid": "0009-0003-1274-535X"
    },
    {
      "affs": [
        1
      ],
      "name": "Hasan AlAjmi"
    },
    {
      "affs": [
        2
      ],
      "name": "Nada Baatiah",
      "orcid": "0000-0001-7060-561X"
    },
    {
      "affs": [
        0
      ],
      "name": "Sara Darag"
    },
    {
      "affs": [
        3
      ],
      "name": "Renad Bakhamis",
      "orcid": "0009-0008-8274-0745"
    },
    {
      "affs": [
        1
      ],
      "name": "Amr Abdelhakim"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/91ab4dhhfw3qf.bib",
  "cited_by": 0,
  "doi": "10.3390/reports9040351",
  "fulltext_url": "https://europepmc.org/articles/PMC13692453",
  "id": "91ab4dhhfw3qf",
  "issns": [
    "2571-841X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42924803",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2742|Wound Healing and Treatments"
    ]
  ],
  "openalex": "W7221753664",
  "pdf_url": "https://europepmc.org/articles/PMC13692453?pdf=render",
  "pmcid": "PMC13692453",
  "pmid": "42924803",
  "published": "2026-10-14",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/91ab4dhhfw3qf.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:33Z",
      "native_id": "MED:42924803",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42924803"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2742|Wound Healing and Treatments",
      "subfield": "general"
    }
  ],
  "title": "Adjunctive Autologous Platelet-Rich Plasma Activated with Autologous Thrombin Serum for a Refractory Below-Knee Amputation Stump Wound: A Case Report.",
  "title_text": "Adjunctive Autologous Platelet-Rich Plasma Activated with Autologous Thrombin Serum for a Refractory Below-Knee Amputation Stump Wound: A Case Report.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:33Z",
  "url": "https://research.draconitic.com/paper/91ab4dhhfw3qf",
  "venue": "Reports (MDPI)",
  "versions": []
}