{
  "abstract": "Introduction: This study investigated the safety and efficacy of single‐needle Rheocarna therapy for chronic limb‐threatening ischemia (CLTI) with wounds.\n\nMethods: Six patients with CLTI involving ulcers unresponsive to revascularization underwent single‐needle Rheocarna treatment. Changes in mean low‐density lipoprotein cholesterol (LDL‐C), fibrinogen, C‐reactive protein (CRP), white blood cell (WBC) count, platelet count, blood flow, and wound improvement were compared between treatment initiation and completion.\n\nResults: The treatment never required discontinuation due to in‐circuit coagulation or hypotension, and its safety was confirmed. After 10 treatment sessions, LDL‐C and fibrinogen removal rates were 24.3% and 24.4%, respectively. Platelet, WBC, and CRP values did not change significantly over time. Blood flow increased during treatment and posttreatment. All patients experienced wound improvement and favorable clinical outcomes.\n\nConclusion: Single‐needle Rheocarna therapy is effective for wound healing in CLTI. If this method applies to nondialysis patients without arteriovenous fistulas, indications for Rheocarna therapy will likely expand.",
  "abstract_shown": true,
  "affiliations": [
    "Cardiovascular Center, Takatsu General Hospital Kawasaki Kanagawa Japan",
    "Department of Cardiology Tokyo Heart Center, Osaki Hospital Tokyo Japan",
    "Department of Clinical Engineer Takatsu General Hospital Kawasaki Kanagawa Japan",
    "Department of Clinical Engineer Tokyo Heart Center, Osaki Hospital Tokyo Japan",
    "Department of Cardiology Tokyo Kamata Hospital Tokyo Japan",
    "Department of Plastic and Reconstructive Surgery Kyorin University Hospital Tokyo Japan",
    "Department of Plastic and Reconstructive Surgery Tokyo Heart Center, Osaki Hospital Tokyo Japan"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Yasutaka Yamauchi"
    },
    {
      "affs": [
        2
      ],
      "name": "Rie Tanaka"
    },
    {
      "affs": [
        2
      ],
      "name": "Reona Kawahira"
    },
    {
      "affs": [
        2
      ],
      "name": "Shingo Nabeta"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Kouhei Naoi"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Kazuhito Kitajima"
    },
    {
      "affs": [
        2
      ],
      "name": "Akira Wada"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Tomonari Takagi"
    },
    {
      "affs": [
        0,
        5,
        6
      ],
      "name": "Norihiko Ohura",
      "orcid": "0000-0002-1139-9307"
    },
    {
      "affs": [
        0,
        1,
        4
      ],
      "name": "Akira Miyamoto"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/91azdaffa7bxp.bib",
  "cited_by": 0,
  "doi": "10.1002/1744-9987.70161",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13738050/",
  "id": "91azdaffa7bxp",
  "issns": [
    "1744-9979",
    "1744-9987"
  ],
  "landing_url": "https://doi.org/10.1002/1744-9987.70161",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2746|Peripheral Artery Disease Management"
    ]
  ],
  "openalex": "W7164055878",
  "pdf_url": null,
  "pmcid": "PMC13738050",
  "pmid": "42261913",
  "published": "2026-06-09",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/91azdaffa7bxp.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:23:07Z",
      "native_id": "PMC13738050",
      "source": "pmc",
      "url": "https://doi.org/10.1002/1744-9987.70161"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Peripheral Artery Disease Management",
      "subfield": "surgery"
    }
  ],
  "title": "Experience With Performing Rheocarna Therapy via the Single‐Needle Method for Treatment of Chronic Limb‐Threatening Ischemia",
  "title_text": "Experience With Performing Rheocarna Therapy via the Single‐Needle Method for Treatment of Chronic Limb‐Threatening Ischemia",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:23:07Z",
  "url": "https://research.draconitic.com/paper/91azdaffa7bxp",
  "venue": "Therapeutic Apheresis and Dialysis",
  "versions": []
}