{
  "abstract": "Wnt/β-catenin signaling is a fundamental regulator of development, tissue homeostasis, and disease progression. Recent studies have suggested functional interactions between Wnt signaling and dopamine D2 receptor (D2DR) pathways, with the AKT–GSK3β axis emerging as a key point of convergence that influences β-catenin stability and transcriptional activity. Through this signaling interface, D2DR may shape diverse biological processes, including neuronal survival, synaptic remodeling, and tumor progression. Importantly, the functional consequences of Wnt–D2DR crosstalk appear to be highly context-dependent, differing substantially between neurological disorders and colorectal cancer. In parallel, advances in organoid systems, single-cell technologies, and real-time biosensing approaches are beginning to provide mechanistic insights into the dynamic regulation of these pathways. Although therapeutic strategies directly targeting Wnt–D2DR interactions remain unavailable, growing evidence supports their potential relevance to disease-specific therapeutic interventions. Therefore, a more comprehensive understanding of this signaling network may provide new opportunities for both mechanistic investigation and translational development.",
  "abstract_shown": true,
  "affiliations": [
    "College of Basic Medicine, Xinjiang Second Medical College, Karamay, 834000, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Zhang Peikun"
    },
    {
      "affs": [
        0
      ],
      "name": "Ge Yuanyan"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhang Xu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/91ce69h930fqv.bib",
  "cited_by": 0,
  "doi": "10.1515/biol-2025-1385",
  "fulltext_url": "https://doi.org/10.1515/biol-2025-1385",
  "id": "91ce69h930fqv",
  "issns": [
    "2391-5412"
  ],
  "landing_url": "https://doi.org/10.1515/biol-2025-1385",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QH301-705.5"
    ],
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      "openalex",
      "1312|Wnt/β-catenin signaling in development and cancer"
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  "openalex": "W7223272605",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-26",
  "publisher": "De Gruyter",
  "ris": "https://research.draconitic.com/paper/91ce69h930fqv.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:47:18Z",
      "native_id": "2a85c57dfc584dc18dead6a88a9cec91",
      "source": "doaj",
      "url": "https://doi.org/10.1515/biol-2025-1385"
    }
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  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Wnt/β-catenin signaling in development and cancer",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Wnt/β-catenin and D2 receptor signaling crosstalk in disease mechanisms",
  "title_text": "Wnt/β-catenin and D2 receptor signaling crosstalk in disease mechanisms",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:47:18Z",
  "url": "https://research.draconitic.com/paper/91ce69h930fqv",
  "venue": "Open Life Sciences",
  "versions": []
}