{
  "abstract": "Objective: Lung cancer is the leading cause of cancer-related mortality worldwide, with lung adenocarcinoma representing the predominant subtype. The increasing incidence of lung adenocarcinoma underscores the urgent need to establish novel therapeutic targets for clinical intervention.\n\nMethods: We performed Mendelian randomization and colocalization analyses on large-scale lung adenocarcinoma genome-wide association study datasets. Bulk transcriptome and single-cell RNA sequencing were further applied to explore the function of candidate targets and related cell types.\n\nResults: Mendelian randomization revealed that elevated RNASET2 expression causally reduced the risk of lung adenocarcinoma (odds ratio = 0.817, 95% confidence interval: 0.754–0.885, p < 0.001), whereas increased BTN3A2 expression was associated with an elevated disease risk. Colocalization analysis supported a shared causal variant between RNASET2 and lung adenocarcinoma (posterior probability of hypothesis 4 = 78.6%). Bulk transcriptome data demonstrated that RNASET2 was upregulated in tumor tissues and was associated with better prognosis. Single-cell RNA sequencing revealed that macrophages were the predominant cell type expressing RNASET2, whereas weak expression was also detected in pulmonary epithelial cells and several other cell populations. There was a trend toward reduced abundance of high RNASET2-expressing macrophage subcluster 0 in tumor tissues, whereas low RNASET2-expressing subcluster 8 tended to accumulate within tumor lesions. Enrichment analysis of their signature genes suggested opposing biological roles in lung adenocarcinoma progression, which warrants further functional verification.\n\nConclusions: RNASET2 is closely associated with the occurrence and prognosis of lung adenocarcinoma. Macrophage-expressed RNASET2 represent a promising candidate molecule for further therapeutic exploration.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Thoracic Surgery, Harbin Medical University Cancer Hospital, China",
    "The Fourth Department of Medical Oncology, Harbin Medical University Cancer Hospital, China",
    "Department of Neurobiology, Harbin Medical University, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yue Shi",
      "orcid": "0009-0004-2257-7529"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiankun Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Fangyu Cai"
    },
    {
      "affs": [
        1
      ],
      "name": "Jian Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jianing Bi"
    },
    {
      "affs": [
        0
      ],
      "name": "Kun Wang"
    },
    {
      "affs": [
        2
      ],
      "name": "Guangyou Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xianglong Kong"
    },
    {
      "affs": [
        0
      ],
      "name": "Yaoguo Lang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jian Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Shidong Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Hai Xu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/91ce7qxrc9eyn.bib",
  "cited_by": 0,
  "doi": "10.1177/03000605261488089",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13735068/",
  "id": "91ce7qxrc9eyn",
  "issns": [
    "0300-0605",
    "1473-2300"
  ],
  "landing_url": "https://doi.org/10.1177/03000605261488089",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Observational Study"
    ],
    [
      "heading",
      "Precision medicine in clinical practice: Evidence, implementation, and outcomes"
    ],
    [
      "openalex",
      "2730|Lung Cancer Research Studies"
    ]
  ],
  "openalex": "W7214124333",
  "pdf_url": null,
  "pmcid": "PMC13735068",
  "pmid": "42773948",
  "published": "2026-09-23",
  "publisher": "SAGE Publications",
  "ris": "https://research.draconitic.com/paper/91ce7qxrc9eyn.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:20:50Z",
      "native_id": "PMC13735068",
      "source": "pmc",
      "url": "https://doi.org/10.1177/03000605261488089"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Lung Cancer Research Studies",
      "subfield": "oncology"
    }
  ],
  "title": "Multiomics analysis identifies RNASET2 as a potential candidate target associated with lung adenocarcinoma",
  "title_text": "Multiomics analysis identifies RNASET2 as a potential candidate target associated with lung adenocarcinoma",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:20:50Z",
  "url": "https://research.draconitic.com/paper/91ce7qxrc9eyn",
  "venue": "The Journal of International Medical Research",
  "versions": []
}