{
  "abstract": "Objective To investigate the expression characteristics of matrix metalloproteinase-12(MMP-12)in tumor-associated macrophages(TAMs)in gastric cancer(GC)tissues and analyze its associations with clinicopathological parameters,Helicobacter pylori(Hp)infection,and prognosis of the patients. Methods Surgical resection samples from 100 GC patients diagnosed pathologically from January 2021 to December 2024 were retrospectively collected. The expression of CD163+ TAMs and MMP-12 in GC tissues and corresponding adjacent normal tissues was detected using multiplex fluorescence immunohistochemistry and quantitatively analyzed. Patients were divided into high-and low-expression groups based on the median proportion of MMP-12+ TAMs,with 50 cases each. Differences in clinicopathological features between the two groups were compared,and the correlation with Hp infection was analyzed. Postoperative follow-up was conducted up to December 2025,and the endpoint event was all-cause mortality. Kaplan-Meier method and log-rank test were used to assess the association between MMP-12 expression and overall survival. Cox proportional hazards regression model was applied to analyze its independent prognostic value. Results The proportion of MMP-12+ TAMs was significantly higher in GC tissues(24.56±5.00)% than that in adjacent normal tissues(17.21±4.50)%(t=12.840,P<0.01). High MMP-12 expression was significantly associated with deeper tumor invasion,higher TNM stage,and a higher rate of lymph node metastasis(P<0.01). The proportion of MMP-12+ TAMs in the Hp infected group(26.70±5.21)% was significantly higher than that in the non-infected group(23.30 ± 4.45)%(t=3.461,P<0.01). Survival analysis showed that patients in the MMP-12 low-expression group had significantly better overall survival compared to the high-expression group(P<0.01). Multivariate Cox regression analysis confirmed that high MMP- 12 expression was an independent influencing factor for all-cause mortality in GC patients(HR=1.416,95%CI:1.180-1.699,P<0.01).Conclusion MMP-12 is highly expressed in TAMs of GC tissues and is closely associated with tumor progression,Hp infection,and poor prognosis,suggesting its potential as a prognostic biomarker in GC.",
  "abstract_shown": true,
  "affiliations": [
    "Gastrointestinal Endoscopy Center,The First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha,Hunan 410007,China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "XIAO Jing"
    },
    {
      "name": "TIAN Guixiang"
    },
    {
      "name": "WU Yangdong"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/91k1ah9gtjkm6.bib",
  "cited_by": 0,
  "doi": "10.13429/j.cnki.cjcr.2026.10.012",
  "fulltext_url": "http://zglcyj.ijournals.cn/zglcyj/ch/reader/create_pdf.aspx?file_no=20261012",
  "id": "91k1ah9gtjkm6",
  "issns": [
    "1674-8182"
  ],
  "landing_url": "https://doi.org/10.13429/j.cnki.cjcr.2026.10.012",
  "language": "zh",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "R"
    ],
    [
      "openalex",
      "2403|Immune cells in cancer"
    ]
  ],
  "openalex": "W7224077157",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-26",
  "publisher": "The Editorial Department of Chinese Journal of Clinical Research",
  "ris": "https://research.draconitic.com/paper/91k1ah9gtjkm6.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:47:10Z",
      "native_id": "8e3eaab3b87448bea647359618d76cda",
      "source": "doaj",
      "url": "https://doi.org/10.13429/j.cnki.cjcr.2026.10.012"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|Immune cells in cancer",
      "subfield": "immunology"
    }
  ],
  "title": "Correlation of MMP-12 expression in tumor-associated macrophages with Helicobacter pylori infection and prognosis in gastric cancer",
  "title_text": "Correlation of MMP-12 expression in tumor-associated macrophages with Helicobacter pylori infection and prognosis in gastric cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:47:10Z",
  "url": "https://research.draconitic.com/paper/91k1ah9gtjkm6",
  "venue": "Zhongguo linchuang yanjiu",
  "versions": []
}