{
  "abstract": "The claustrum is a broadly connected subcortical structure proposed to coordinate distributed cortical activity. Claustral neurons are recruited during synchronized brain states and contribute to sleep-dependent memory consolidation, primarily through effects on cortical dynamics. Yet the claustrum also innervates the subicular complex, a major hippocampal output node, raising the possibility that it may regulate both cortical state and hippocampo-cortical dialogue during sleep. Here, we identify a projection-defined population of claustral neurons targeting the subicular complex, CLAsc, that is preferentially recruited during slow-wave sleep and tracks cortical and subicular sleep dynamics. Optogenetic activation of CLAsc neurons during post-learning sleep enhanced spatial memory consolidation without detectable changes in ripple occurrence or slow-oscillation-spindle coupling. Instead, CLAsc activation imposed a stereotyped cortical-subicular motif: a brief gamma-rich Up state followed by a coordinated Down state across prefrontal, retrosplenial and subicular regions. Within this gamma-rich Up state, interareal coherence increased, gamma bursts became synchronized, and lagged directed interactions were transiently reorganized, including an enhanced prefrontal-to-subicular component. Together, these findings identify the claustrum as a state-dependent coordinator that transforms ongoing cortical and hippocampal-output activity into coordinated network transitions during sleep, providing a circuit mechanism through which distributed brain states may support memory consolidation.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "Coline Portet"
    },
    {
      "name": "Flora Thellier"
    },
    {
      "name": "Matthieu Aguilera"
    },
    {
      "name": "Thomas Blondel"
    },
    {
      "name": "Karin Herbeaux"
    },
    {
      "name": "Caroline Mursch"
    },
    {
      "name": "Jesse Jackson"
    },
    {
      "name": "Demian Battaglia"
    },
    {
      "name": "Yaroslav Sych"
    },
    {
      "name": "Romain Goutagny"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/91vqt00y0cyfb.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.08.13.744575",
  "fulltext_url": null,
  "id": "91vqt00y0cyfb",
  "issns": [],
  "landing_url": "https://hal.science/hal-05766566v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "2805|Memory and Neural Mechanisms"
    ]
  ],
  "openalex": "W7203703573",
  "pdf_url": "https://www.biorxiv.org/content/biorxiv/early/2026/08/18/2026.08.13.744575.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-18",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/91vqt00y0cyfb.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:42Z",
      "native_id": "hal-05766566",
      "source": "hal",
      "url": "https://hal.science/hal-05766566v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2805|Memory and Neural Mechanisms",
      "subfield": "neuroscience"
    }
  ],
  "title": "Claustral pathway coordinates distributed cortical dynamics with hippocampal output during sleep to promote memory consolidation",
  "title_text": "Claustral pathway coordinates distributed cortical dynamics with hippocampal output during sleep to promote memory consolidation",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:42Z",
  "url": "https://research.draconitic.com/paper/91vqt00y0cyfb",
  "venue": "HAL",
  "versions": []
}