{
  "abstract": "Machine learning-based disease prediction models can assist with disease diagnosis and early detection. This study aimed to identify the risk factors for developmental dysplasia of the hip (DDH) and develop multiple machine learning-based models to support screening and risk stratification for DDH. A retrospective analysis of 12,105 infants screened for DDH between January 2020 and December 2022 at Shenzhen Children's Hospital was performed to collect information on physical examination and risk factors. After univariate and multivariate screening, age-stratified sampling was performed on 11,898 DDH-negative patients to match the age distribution of 207 DDH-positive patients, thereby reducing potential bias. These balanced cohorts were randomly split into training and test sets (at an 8:2 ratio) under both 1:1 and 1:2 positive-to-negative ratios. Predictive modeling was based on random forest, support vector machine, logistic regression, k-nearest neighbor, light gradient boosting machine, and extreme gradient boosting (XGBoost). Twelve variables were included in the model. The XGBoost model trained on 1:1 data was chosen as the best model [area under the curve (AUC): 0.883, accuracy: 0.807, precision: 0.744, F1 score: 0.800, recall (sensitivity): 0.865, and specificity: 0.761]. External validation using data from Jinhua Municipal Central Hospital provided preliminary evidence of transferability [AUC: 0.909, accuracy: 0.838, precision: 0.829, F1 score: 0.840, recall (sensitivity): 0.850, and specificity: 0.825]. Skin pattern asymmetry, restriction of hip abduction, swaddling, breech presentation, and female sex were the top five most important predictive variables. The XGBoost model can be used to support early clinical screening and risk stratification for DDH, helping clinicians identify infants who should undergo hip ultrasonography.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Medical Ultrasound, Jinhua Municipal Central Hospital, Zhejiang, China.",
    "Department of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy.",
    "Orthopedic and Traumatology Unit, Azienda Ospedaliero-Universitaria di Sassari, Sassari, Italy.",
    "Department of Medical Ultrasound, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China.",
    "Department of Medical Ultrasonics, Affiliated Shenzhen Children's Hospital of Shantou University Medical College, Shenzhen, China.",
    "Department of Orthopedics, Affiliated Shenzhen Children's Hospital of Shantou University Medical College, Shenzhen, China.",
    "Department of Medical Ultrasonics, Shenzhen Children's Hospital & Shenzhen University Medical School, Shenzhen, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Shuang-Shuang Zhang"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Gianfilippo Caggiari"
    },
    {
      "affs": [
        3
      ],
      "name": "Xiao-Yi Chen"
    },
    {
      "affs": [
        4
      ],
      "name": "Bing-Xuan Huang"
    },
    {
      "affs": [
        5
      ],
      "name": "Han-Sheng Deng"
    },
    {
      "affs": [
        4,
        6
      ],
      "name": "Na Xu"
    },
    {
      "affs": [
        5
      ],
      "name": "Wei Shi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/925t73gsx5yq6.bib",
  "cited_by": 0,
  "doi": "10.3389/fdgth.2026.1912106",
  "fulltext_url": "https://europepmc.org/articles/PMC13713713",
  "id": "925t73gsx5yq6",
  "issns": [
    "2673-253X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42953024",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2746|Hip disorders and treatments"
    ]
  ],
  "openalex": "W7221827937",
  "pdf_url": "https://europepmc.org/articles/PMC13713713?pdf=render",
  "pmcid": "PMC13713713",
  "pmid": "42953024",
  "published": "2026-10-14",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/925t73gsx5yq6.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:41Z",
      "native_id": "MED:42953024",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42953024"
    },
    {
      "first_seen": "2026-10-31T12:24:13Z",
      "native_id": "PMC13713713",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fdgth.2026.1912106"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Hip disorders and treatments",
      "subfield": "surgery"
    }
  ],
  "title": "Machine learning-based personalized prediction of developmental dysplasia of the hip using risk factors and clinical examination.",
  "title_text": "Machine learning-based personalized prediction of developmental dysplasia of the hip using risk factors and clinical examination.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:21:20Z",
  "url": "https://research.draconitic.com/paper/925t73gsx5yq6",
  "venue": "Frontiers in digital health",
  "versions": []
}