{
  "abstract": "Background\n\nData on patients with amyotrophic lateral sclerosis (ALS) admitted to the intensive care unit (ICU) for acute respiratory failure are scarce, and early prognostic markers are lacking.Methods\n\nWe conducted a retrospective cohort study of consecutive patients with ALS admitted for acute respiratory failure to two ICUs of a tertiary referral center between 2016 and 2022. The primary outcome was 3-month mortality. Factors associated with 3-month mortality were assessed using multivariable Cox proportional hazards regression. Survival and functional outcomes were evaluated up to 12 months.Results\n\nAmong 139 patients [median age 66 (IQR 57-73) years, 61.2% being men], 109 (78.4%) patients presented with hypercapnia and 82 (59.0%) with hypoxemia (defined as PaO₂/FiO₂ ratio < 300) at ICU admission, with frequent overlap between both conditions. Non-invasive ventilation was used in 79.9% of patients, while 13.7% were intubated, and 2.2% underwent tracheostomy. Three-month mortality was 48.2%, increasing to 61.2% and 74.1% at 6 and 12 months respectively. In multivariable analysis, hypoxemia at ICU admission was independently associated with increased 3-month mortality (HR = 2.27, 95% CI: 1.28-4.01; P = 0.005), along with older age (HR=1.03 per year, 95% CI: 1.00-1.06; P = 0.035). Among patients alive at 3 months, a majority (79.2%) were living at home.Conclusion\n\nICU admission for acute respiratory failure in ALS is associated with substantial short-term mortality, consistent with the poor prognosis inherent to the natural history of the disease. Hypoxemia at admission identifies a subgroup at particularly high risk of death and may help inform early prognostic assessment and shared decision-making. However, patients who survive the acute ICU phase frequently achieve favorable short-term outcomes, with most living at home at 3 months.",
  "abstract_shown": true,
  "affiliations": [
    "AP-HP, Groupe Hospitalier Universitaire APHP-Sorbonne Université, site Pitié-Salpêtrière, Service de Médecine Intensive et Réanimation à orientation neurologique, Paris, France.",
    "Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Paris, France.",
    "AP-HP, Groupe Hospitalier Universitaire APHP-Sorbonne Université, site Pitié-Salpêtrière, Département de neurologie, Centre d'Investigation Clinique Neurosciences, Hôpital Pitié-Salpêtrière, Paris, France.",
    "Department of Neurology, Paris ALS Center, Pitie-Salpetriere University Hospital - Assistance Publique - Hopitaux de Paris, France.",
    "Service de Pneumologie (Département R3S), AP-HP, Groupe Hospitalier Universitaire APHP-Sorbonne Université, Hôpital Pitié- Salpêtrière, Paris, F-75013, France.",
    "University Paris Cité, Inserm UMR_S1124, 75270, Paris Cedex 06, France.",
    "Sorbonne Université, INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France.",
    "AP-HP, Groupe Hospitalier Universitaire APHP-Sorbonne Université, site Pitié-Salpêtrière, Service de Médecine Intensive et Réanimation (Département R3S), F-75013 Paris, France.",
    "INSERM, UMRS1158 Neurophysiologie respiratoire expérimentale et clinique, Paris, France.",
    "Groupe de Recherche Clinique en REanimation et Soins intensifs du Patient en Insuffisance Respiratoire aiguE (GRC-RESPIRE), Sorbonne Université, Paris, France.",
    "Brain Liver Pitié-Salpêtrière Study Group, INSERM UMR_S 938, Centre de recherche Saint-Antoine, Maladies métaboliques, biliaires et fibro-inflammatoire du foie, Institute of Cardiometabolism and Nutrition, Paris, France."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Adam Celier"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Aymeric Lanore"
    },
    {
      "affs": [
        3
      ],
      "name": "Adele Hesters"
    },
    {
      "affs": [
        4
      ],
      "name": "Sarah Hussein"
    },
    {
      "affs": [
        0
      ],
      "name": "Raouf Benchikh"
    },
    {
      "affs": [
        3,
        5
      ],
      "name": "Gaelle Bruneteau"
    },
    {
      "affs": [
        4,
        6
      ],
      "name": "Capucine Morélot-Panzini"
    },
    {
      "affs": [
        7,
        8
      ],
      "name": "Mélodie Parfait"
    },
    {
      "affs": [
        0
      ],
      "name": "Mathilde Piljan"
    },
    {
      "affs": [
        0
      ],
      "name": "Loic Le Guennec"
    },
    {
      "affs": [
        0,
        9,
        10
      ],
      "name": "Nicolas Weiss"
    },
    {
      "affs": [
        0
      ],
      "name": "Sophie Demeret"
    },
    {
      "affs": [
        7
      ],
      "name": "Julien Mayaux"
    },
    {
      "affs": [
        0,
        9
      ],
      "name": "Clemence Marois"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/92d0p0q695bd8.bib",
  "cited_by": 0,
  "doi": "10.1016/j.aicoj.2026.100183",
  "fulltext_url": "https://europepmc.org/articles/PMC13695101",
  "id": "92d0p0q695bd8",
  "issns": [
    "2110-5820"
  ],
  "landing_url": "https://europepmc.org/article/MED/42926935",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2728|Amyotrophic Lateral Sclerosis Research"
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  ],
  "openalex": "W7221556119",
  "pdf_url": "https://europepmc.org/articles/PMC13695101?pdf=render",
  "pmcid": "PMC13695101",
  "pmid": "42926935",
  "published": "2026-10-12",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/92d0p0q695bd8.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:18Z",
      "native_id": "MED:42926935",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42926935"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Amyotrophic Lateral Sclerosis Research",
      "subfield": "neurology"
    }
  ],
  "title": "Outcomes of patients with amyotrophic lateral sclerosis admitted to the ICU for acute respiratory failure.",
  "title_text": "Outcomes of patients with amyotrophic lateral sclerosis admitted to the ICU for acute respiratory failure.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:18Z",
  "url": "https://research.draconitic.com/paper/92d0p0q695bd8",
  "venue": "Annals of intensive care",
  "versions": []
}