{
  "abstract": "The skeleton is a frequent site of metastatic spread, leading to skeletal-related events (SREs) such as pathological fractures, spinal cord compression, and refractory pain that profoundly impact patient survival and quality of life. Traditionally managed by a triad of radiotherapy, surgery, and systemic treatments, the landscape of bone metastasis care has undergone a major paradigm shift. Interventional Radiology (IR) has emerged as the \"fourth pillar\" of oncology, evolving from a palliative last-resort tool into a proactive specialty integrated into precision medicine and multidisciplinary decision-making. Through high-resolution image guidance, IR provides critical diagnostic tissue sampling for molecular profiling, immediate mechanical reinforcement via hybrid stabilization-combining percutaneous osteosynthesis and cementoplasty-and local tumor control through thermal ablation and cryoablation.\n\nBeyond its mechanical and local effects, an emerging body of research highlights the immunomodulatory potential of cryoablation and thermablation technics. IR-induced tumor necrosis may act as a potent \"in situ\" vaccine, releasing tumor-associated antigens and damage-associated molecular patterns that could trigger a systemic abscopal effect, especially when synergistic with immune checkpoint inhibitors. This review details the state-of-the-art IR techniques, from devascularization via embolization to advanced cryoablation, emphasizing their strategic integration into modern care pathways. It highlights the transition from simple symptom management to aggressive, curative-intent strategies in the era of personalized oncology, where IR serves as a bridge between conservative medical therapy and invasive surgical intervention.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "Nicolas Stacoffe"
    },
    {
      "name": "Emmanuel Mesny"
    },
    {
      "name": "Mathilde Proriol"
    },
    {
      "name": "Aurélie Fontana"
    },
    {
      "name": "Bastien Chalamet"
    },
    {
      "name": "Mohamed-Ilyess Benrejeb"
    },
    {
      "name": "Edith Bonnelye"
    },
    {
      "name": "Jean-Baptiste Pialat"
    },
    {
      "name": "Cyrille Confavreux"
    },
    {
      "name": "Emmanuel Massy"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/92htk5cqr5t73.bib",
  "cited_by": 1,
  "doi": "10.1016/j.jbspin.2026.106076",
  "fulltext_url": null,
  "id": "92htk5cqr5t73",
  "issns": [
    "1297-319X"
  ],
  "landing_url": "https://hal.science/hal-05761696v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "2746|Management of metastatic bone disease"
    ]
  ],
  "openalex": "W7160953157",
  "pdf_url": "https://hal.science/hal-05761696/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-23",
  "publisher": "Elsevier Masson",
  "ris": "https://research.draconitic.com/paper/92htk5cqr5t73.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:39Z",
      "native_id": "hal-05761696",
      "source": "hal",
      "url": "https://hal.science/hal-05761696v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Management of metastatic bone disease",
      "subfield": "surgery"
    }
  ],
  "title": "Interventional radiology in bone metastases: Current concepts and perspectives",
  "title_text": "Interventional radiology in bone metastases: Current concepts and perspectives",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:39Z",
  "url": "https://research.draconitic.com/paper/92htk5cqr5t73",
  "venue": "Joint Bone Spine",
  "versions": []
}