{
  "abstract": "Background: Aerobic exercise is recommended within lifestyle management for polycystic ovary syndrome (PCOS), but its effects on anthropometric and endocrine outcomes remain inconsistent. Methods: Five databases were searched from inception through July 2026. Controlled trials of structured aerobic or aerobic-oriented exercise lasting at least four weeks were eligible when the comparator did not receive an exercise program expected to improve aerobic fitness. Between-group changes were expressed as Hedges’ g and pooled using random-effects models with cluster-robust small-sample inference. Subgroup, univariable meta-regression, and dose–response analyses were exploratory. Results: Twenty-two reports representing 20 independent trials were included. The pooled standardized estimate marginally favored exercise for body weight (g = −0.09, 95% CI −0.13 to −0.05), although its magnitude was trivial and the 95% prediction interval crossed the null (−0.29 to 0.11). Exercise was associated with lower body mass index (g = −0.20, 95% CI −0.33 to −0.06), waist-to-hip ratio (g = −0.36, 95% CI −0.56 to −0.19), total testosterone (g = −0.43, 95% CI −0.67 to −0.20), and free testosterone (g = −0.60, 95% CI −0.99 to −0.21), and with higher sex hormone-binding globulin (SHBG; g = 0.24, 95% CI 0.04 to 0.44). No clear pooled effects were observed for waist circumference, body fat percentage, free androgen index, dehydroepiandrosterone sulfate, or anti-Müllerian hormone. Follicle-stimulating hormone and luteinizing hormone estimates lay at the statistical boundary and were heterogeneous; leave-one-study-out inference was also unstable for free testosterone and SHBG. Certainty was low or very low across outcomes. Conclusions: Aerobic or aerobic-oriented exercise showed favorable pooled differences in selected anthropometric and androgen-related markers, but low certainty and the sensitivity of some estimates preclude an endocrine-targeted dose or reproductive-benefit claim.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Applied Psychology, School of Health Management, Guangzhou Medical University, Guangzhou 511436, China",
    "School of Physical Education and Training, Xi’an Physical Education University, No. 1 Dongcheng South Road, Huyi District, Xi’an 710399, China",
    "Nutrilite Health Institute, Amway R&D Center, 720 Cailun Road, Shanghai 201203, China",
    "College of Sports Training, Tianjin University of Sport, Tianjin 301617, China"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Lanxin Qiu"
    },
    {
      "affs": [
        2
      ],
      "name": "Yunzhi Emma Huang"
    },
    {
      "affs": [
        3
      ],
      "name": "Mingnan Zhuang"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Juntao Kan",
      "orcid": "0000-0001-7280-6394"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Zhengqi Qiu",
      "orcid": "0000-0003-0033-0512"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/92nj35hbqb8cy.bib",
  "cited_by": 0,
  "doi": "10.3390/metabo16100745",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13706977/?tool=EBI",
  "id": "92nj35hbqb8cy",
  "issns": [
    "2218-1989"
  ],
  "landing_url": "https://www.mdpi.com/2218-1989/16/10/745",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2743|Ovarian function and disorders"
    ]
  ],
  "openalex": "W7220463121",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13706977/pdf/?tool=EBI",
  "pmcid": "PMC13706977",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/92nj35hbqb8cy.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:00Z",
      "native_id": "10.3390/metabo16100745",
      "source": "crossref",
      "url": "https://www.mdpi.com/2218-1989/16/10/745"
    },
    {
      "first_seen": "2026-10-30T12:21:40Z",
      "native_id": "PMC:PMC13706977",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13706977"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2743|Ovarian function and disorders",
      "subfield": "reproductive-child"
    }
  ],
  "title": "Aerobic and Aerobic-Oriented Exercise for Anthropometric, Androgen-Related, and Reproductive Endocrine Outcomes in Polyendocrine Metabolic Ovarian Syndrome (Polycystic Ovary Syndrome): A Systematic Review and Meta-Analysis",
  "title_text": "Aerobic and Aerobic-Oriented Exercise for Anthropometric, Androgen-Related, and Reproductive Endocrine Outcomes in Polyendocrine Metabolic Ovarian Syndrome (Polycystic Ovary Syndrome): A Systematic Review and Meta-Analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:40Z",
  "url": "https://research.draconitic.com/paper/92nj35hbqb8cy",
  "venue": "Metabolites",
  "versions": []
}