{
  "abstract": "Artificial water channels (AWCs) are synthetic systems biomimicking natural aquaporins (AQPs) that selectively transport water while rejecting ions. Amphiphilic rim-differentiated pillar[5]arenes and pillar[6]arenes, featuring cationic methylammonium and alkyl substituents on opposite rims, spontaneously assemble into two-dimensional channels with tunable pore sizes and channel lengths. Herein, we considered the alkyl chains (butyl-C4 and decatyl-C10) of these channels in relation to membrane partitioning and investigated the potential structure-activity relationships within the lipid bilayer. A synergistic effect of a large pore and favorable lipophilicity led to the highest water permeation (∼1 × 10 8 water molecules per channel per second) for AP-P6A-C10, as well as ion rejection. The present channels may be regarded as a rare biomimetic example of artificial channels that preferentially transport water while presenting low proton or ion transport activity.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "Dan-Dan Su"
    },
    {
      "name": "Tan-Hao Shi"
    },
    {
      "name": "Tomoki Ogoshi"
    },
    {
      "name": "Mihail Barboiu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/92ps9y8b09nbr.bib",
  "cited_by": 0,
  "doi": "10.1021/jacs.6c11291",
  "fulltext_url": null,
  "id": "92ps9y8b09nbr",
  "issns": [
    "0002-7863",
    "1520-5126"
  ],
  "landing_url": "https://hal.umontpellier.fr/hal-05774440v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.chim"
    ],
    [
      "openalex",
      "1605|Supramolecular Chemistry and Complexes"
    ]
  ],
  "openalex": "W7171398195",
  "pdf_url": "https://hal.umontpellier.fr/hal-05774440/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-27",
  "publisher": "American Chemical Society",
  "ris": "https://research.draconitic.com/paper/92ps9y8b09nbr.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:46Z",
      "native_id": "hal-05774440",
      "source": "hal",
      "url": "https://hal.umontpellier.fr/hal-05774440v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Supramolecular Chemistry and Complexes",
      "subfield": "organic"
    }
  ],
  "title": "Trimethylammonium-Substituted Amphiphilic Pillar[ n ]arene Channels for Selective Water Permeation",
  "title_text": "Trimethylammonium-Substituted Amphiphilic Pillar[ n ]arene Channels for Selective Water Permeation",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:46Z",
  "url": "https://research.draconitic.com/paper/92ps9y8b09nbr",
  "venue": "Journal of the American Chemical Society",
  "versions": []
}