{
  "abstract": "Background: The red blood cell distribution width to albumin ratio (RAR) is a novel biomarker reflecting systemic inflammation and metabolic status. This study investigated the association between RAR and cardiovascular outcomes in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).\n\nMethods: This cohort study analyzed data from the National Health and Nutrition Examination Survey (NHANES). MASLD participants were categorized by RAR levels. Regression models and restricted cubic splines (RCS) assessed the relationships of RAR with life’s crucial 9 (LC9), cardiovascular disease (CVD), all-cause mortality, and cardiovascular mortality.\n\nResults: A total of 4,419 participants with MASLD were included in our study. Multivariable analysis showed higher RAR was significantly associated with lower LC9 (β = − 3.59, 95% CI: − 4.46 to − 2.73) and with higher odds of prevalent CVD (OR = 1.88, 95% CI: 1.34 to 2.64). Cox regression analysis revealed significant positive associations between RAR and all-cause mortality (HR = 2.13, 95% CI: 1.69 to 2.69) as well as cardiovascular mortality (HR = 3.05, 95% CI: 1.71 to 5.42). Nonlinear relationships were identified between RAR and cardiovascular outcomes. Machine learning revealed RAR as a key determinant of cardiovascular risk in MASLD patients.\n\nConclusion: RAR is a simple and reliable indicator associated with adverse cardiovascular outcomes in MASLD patients.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xiao-Xuan Tang"
    },
    {
      "affs": [
        0
      ],
      "name": "Meng-Xi Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Yu-Jia Gao"
    },
    {
      "affs": [
        0
      ],
      "name": "Yi-Ran Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Chong Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Bin Zhang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/92thzkfag16yk.bib",
  "cited_by": 0,
  "doi": "10.1186/s12872-026-06396-2",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13732851/",
  "id": "92thzkfag16yk",
  "issns": [
    "1471-2261"
  ],
  "landing_url": "https://doi.org/10.1186/s12872-026-06396-2",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2721|Liver Disease Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7201883686",
  "pdf_url": null,
  "pmcid": "PMC13732851",
  "pmid": "42983650",
  "published": "2026-08-07",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/92thzkfag16yk.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:22:45Z",
      "native_id": "PMC13732851",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12872-026-06396-2"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:2705|Acute Myocardial Infarction Research",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Association between the red blood cell distribution width to albumin ratio and cardiovascular outcomes in MASLD patients: a national cohort study integrating machine learning",
  "title_text": "Association between the red blood cell distribution width to albumin ratio and cardiovascular outcomes in MASLD patients: a national cohort study integrating machine learning",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:22:45Z",
  "url": "https://research.draconitic.com/paper/92thzkfag16yk",
  "venue": "BMC Cardiovascular Disorders",
  "versions": []
}