{
  "abstract": "Objective\n\nTo investigate how ischemic stroke alters neural activity in the caudal forelimb area (CFA) and identify electrophysiological mechanisms underlying post-stroke motor deficits.Methods\n\nLocal field potentials were recorded bilaterally from ipsilateral and contralateral CFA in rats under anesthesia and during a single-pellet retrieval task. Analyses included spectral power across canonical frequency bands, aperiodic 1/f slope characterization of excitation-inhibition balance, and cross-frequency coupling assessment of interhemispheric coordination.Results\n\nStroke induced widespread bilateral disruptions in oscillatory dynamics across delta, theta, alpha, beta, and gamma bands. The aperiodic 1/f slope shifted, reflecting altered excitation-inhibition balance. Cross-frequency coupling between hemispheres, particularly low-frequency phase to gamma amplitude, was reorganized, indicating impaired interhemispheric coordination and bilateral motor network imbalance. Notably, the main experimental cohort did not include a sham-operated control group; however, a pilot experiment with three sham and three MCAO animals, conducted using identical procedures, provided supportive evidence for the stability of key measures under sham conditions.Conclusions\n\nThis study demonstrates that ischemic stroke induces coordinated alterations in spectral organization, excitation-inhibition balance, and cross-frequency interactions within the bilateral caudal forelimb cortex. These findings indicate that post-stroke motor dysfunction arises from disrupted, state-dependent dynamics of distributed motor networks rather than isolated changes within the lesioned hemisphere.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurosurgery, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.",
    "Renmin Hospital of Wuhan University, Wuhan, China.",
    "School of Information Engineering, Guangdong University of Technology, Guangzhou, China.",
    "School of Automation Science and Engineering, South China University of Technology, Guangzhou, China. auyqli@scut.edu.cn.",
    "Department of Neurosurgery, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China. dr_guoy@163.com."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Cheng'an Cao"
    },
    {
      "affs": [
        2
      ],
      "name": "Di Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Jin Gong"
    },
    {
      "affs": [
        0
      ],
      "name": "Shuangqi Gao"
    },
    {
      "affs": [
        0
      ],
      "name": "Jianwei Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Chaoran Jia"
    },
    {
      "affs": [
        0
      ],
      "name": "Hongyu Liu"
    },
    {
      "affs": [
        3
      ],
      "name": "Yuanqing Li"
    },
    {
      "affs": [
        4
      ],
      "name": "Ying Guo"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/92vk8fp9q57c3.bib",
  "cited_by": 0,
  "doi": "10.1186/s12993-026-00355-9",
  "fulltext_url": "https://europepmc.org/articles/PMC13721534",
  "id": "92vk8fp9q57c3",
  "issns": [
    "1744-9081"
  ],
  "landing_url": "https://europepmc.org/article/MED/42958553",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2742|Stroke Rehabilitation and Recovery"
    ]
  ],
  "openalex": "W7171146343",
  "pdf_url": "https://europepmc.org/articles/PMC13721534?pdf=render",
  "pmcid": "PMC13721534",
  "pmid": "42958553",
  "published": "2026-07-25",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/92vk8fp9q57c3.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T00:20:48Z",
      "native_id": "MED:42958553",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42958553"
    },
    {
      "first_seen": "2026-11-03T12:22:12Z",
      "native_id": "PMC13721534",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12993-026-00355-9"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "journal-openalex:F28",
      "subfield": "neuroscience"
    }
  ],
  "title": "Bilateral cortical network disruptions in the rat caudal forelimb area after unilateral stroke.",
  "title_text": "Bilateral cortical network disruptions in the rat caudal forelimb area after unilateral stroke.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:22:12Z",
  "url": "https://research.draconitic.com/paper/92vk8fp9q57c3",
  "venue": "Behavioral and brain functions : BBF",
  "versions": []
}