{
  "abstract": "Background Gastric cancer (GC) has a high incidence in East Asia, yet early detection remains limited. Methods In this multiphase study, 395 participants (96 GC, 72 precancerous lesions, 227 healthy donors) were enrolled. Plasma IFNL3 levels were measured using ELISA. Mendelian randomization was used to assess the causality between IFNL3 and GC. Receiver operating characteristic curves were used to calculate diagnostic efficiency in comparison between IFNL3 and traditional biomarkers (alpha fetoprotein [AFP], carcinoembryonic antigen [CEA], and cancer antigen 19‐9 [CA19‐9]). Results Bidirectional Mendelian randomization analysis suggested a potential association between plasma IFNL3 and GC in East Asians. In Test phase, plasma IFNL3 demonstrated superior diagnostic performance in differentiating GC from HDs (AUC = 0.901, 95% CI: 0.866–0.935) compared to AFP, CEA, and CA19‐9. IFNL3 levels correlated with disease progression, increasing progressively across clinical stages. IFNL3 mRNA was also higher in cancerous tissues compared to normal and para‐cancerous tissues. In Validation phase, IFNL3 exhibited high diagnostic specificity. In Extension phase, plasma IFNL3 showed distinct diagnostic potential for differentiating chronic non‐atrophic gastritis (CNAG), atrophic intestinal metaplasia (AIM), low‐grade intraepithelial neoplasia (LGIN), and high‐grade intraepithelial neoplasia (HGIN). Conclusions Plasma IFNL3 levels were increased in gastric cancer and correlated with disease progression. However, its value as a diagnostic biomarker requires validation in larger, stage‐adjusted studies.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Gastroenterology The Second Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou People's Republic of China",
    "Key Laboratory of Traditional Chinese Medicine for the Treatment of Intestine‐Liver of Zhejiang Province Hangzhou People's Republic of China",
    "School of Basic Medical Sciences Zhejiang Chinese Medical University Hangzhou People's Republic of China",
    "Zhejiang Key Laboratory of Blood‐Stasis‐Toxin Syndrome Hangzhou People's Republic of China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Yunmeng Nie",
      "orcid": "0009-0002-2342-655X"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jihong Zhong"
    },
    {
      "affs": [
        0
      ],
      "name": "Siyi Ni"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yingchao Liu",
      "orcid": "0000-0002-1854-8432"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Shuo Zhang",
      "orcid": "0000-0003-1120-5872"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Guangji Zhang",
      "orcid": "0000-0003-4525-9422"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/92yswpbq4bwxr.bib",
  "cited_by": 0,
  "doi": "10.1002/cam4.72381",
  "fulltext_url": "https://doi.org/10.1002/cam4.72381",
  "id": "92yswpbq4bwxr",
  "issns": [
    "2045-7634"
  ],
  "landing_url": "https://doi.org/10.1002/cam4.72381",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "lcc",
      "RC254-282"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": "PMC13731846",
  "pmid": "42978105",
  "published": "2026-11-03",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/92yswpbq4bwxr.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T14:20:47Z",
      "native_id": "11b0171d85044a298a9e3c05cd2a3692",
      "source": "doaj",
      "url": "https://doi.org/10.1002/cam4.72381"
    },
    {
      "first_seen": "2026-11-08T12:21:58Z",
      "native_id": "PMC13731846",
      "source": "pmc",
      "url": "https://doi.org/10.1002/cam4.72381"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RC254-282",
      "subfield": "oncology"
    }
  ],
  "title": "Plasma IFNL3 for Gastric Cancer Detection and Monitoring in East Asians: A Multiphase Study",
  "title_text": "Plasma IFNL3 for Gastric Cancer Detection and Monitoring in East Asians: A Multiphase Study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:21:58Z",
  "url": "https://research.draconitic.com/paper/92yswpbq4bwxr",
  "venue": "Cancer Medicine",
  "versions": []
}