{
  "abstract": "40-Hz ASSR is reduced in schizophrenia, but it is unclear if this reflects altered auditory input or cortical E/I dynamics. We hypothesized that similar group differences could arise via distinct model mechanisms. EEG gamma% and ITPC from 21 HC and 21 SCZ constrained an auditory front-end coupled to a Wilson-Cowan E/I model. We compared front-end-restricted, back-end-restricted, and full-joint parameter searches, plus perturbation and fixed-point analyses. HC means exceeded SCZ for both metrics (not individually significant). All three models reproduced HC>SCZ but located group differences differently: front-end via input transformation, back-end via cortical dynamics, full-joint via both. The full-joint solution was most robust to perturbation. Fixed-point analysis revealed similar outputs with distinct local dynamics. All models reproduced the HC>SCZ pattern, suggesting schizophrenia pathophysiology may involve altered sensory encoding, altered cortical E/I, or both. This framework enables future patient-level mechanistic comparison and, after validation, may support individualized stratification.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": "2608.29104",
  "author_total": 3,
  "authors": [
    {
      "name": "Wenjun Xia"
    },
    {
      "name": "Yan Xu"
    },
    {
      "name": "Zhengdi Zhang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/931ra4h3ba552.bib",
  "cited_by": 0,
  "doi": "10.48550/arxiv.2608.29104",
  "fulltext_url": null,
  "id": "931ra4h3ba552",
  "issns": [],
  "landing_url": "https://arxiv.org/abs/2608.29104",
  "language": null,
  "licence": "CC-BY-NC-SA-4.0",
  "licence_label": "CC BY-NC-SA 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by-nc-sa/4.0/",
  "metadata_licence": "CC0-1.0",
  "native_subjects": [
    [
      "arxiv",
      "q-bio.NC"
    ],
    [
      "openalex",
      "2805|Neural dynamics and brain function"
    ]
  ],
  "openalex": "W7204943285",
  "pdf_url": "https://arxiv.org/pdf/2608.29104",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-29",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/931ra4h3ba552.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:49Z",
      "native_id": "2608.29104",
      "source": "arxiv",
      "url": "https://arxiv.org/abs/2608.29104"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "arxiv:q-bio.NC",
      "subfield": "neuroscience"
    }
  ],
  "title": "Front-end and Back-end Computational Modeling of 40-Hz Auditory Steady-State Response Abnormalities in Schizophrenia",
  "title_text": "Front-end and Back-end Computational Modeling of 40-Hz Auditory Steady-State Response Abnormalities in Schizophrenia",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:49Z",
  "url": "https://research.draconitic.com/paper/931ra4h3ba552",
  "venue": "arXiv",
  "versions": []
}